{"id":7703,"date":"2026-04-15T23:16:54","date_gmt":"2026-04-15T23:16:54","guid":{"rendered":"https:\/\/bristishpharmacy.co.uk\/?post_type=product&#038;p=7703"},"modified":"2026-09-17T19:21:20","modified_gmt":"2026-09-17T19:21:20","slug":"oxypro-30-mg","status":"publish","type":"product","link":"https:\/\/bristishpharmacy.co.uk\/de\/shop\/oxypro-30-mg\/","title":{"rendered":"Oxypro 30 mg"},"content":{"rendered":"<h1>\u00a0<\/h1>\n<div class=\"container\">\n<div id=\"model-response-message-contentr_dcc3ccf5bc7f0b74\" class=\"markdown markdown-main-panel md-content enable-luminous-fast-follows enable-updated-hr-color stronger tutor-markdown-rendering\" dir=\"ltr\" aria-live=\"polite\">\n<h3 data-path-to-node=\"3\">Clinical Monograph: Oxypro 30 mg (Oxycodone Hydrochloride Extended-Release)<\/h3>\n<h2 data-path-to-node=\"4\">1. Classification and Chemical Overview<\/h2>\n<p data-path-to-node=\"5\">Oxycodone is a semi-synthetic phenanthrene-derivative opioid agonist synthesized from the opium alkaloid thebaine. Chemically designated as <span class=\"math-inline\" data-math=\"(5\\alpha,14\\alpha)\" data-index-in-node=\"140\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mopen\">(<\/span><span class=\"mord\">5<\/span><span class=\"mord mathnormal\">\u03b1<\/span><span class=\"mpunct\">,<\/span><span class=\"mord\">14<\/span><span class=\"mord mathnormal\">\u03b1<\/span><span class=\"mclose\">)<\/span><\/span><\/span><\/span><\/span>-4,5-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one hydrochloride. Under the Anatomical Therapeutic Chemical (ATC) system, oxycodone is indexed under N02AA05.<\/p>\n<ul data-path-to-node=\"6\">\n<li>\n<p data-path-to-node=\"6,0,0\"><b data-path-to-node=\"6,0,0\" data-index-in-node=\"0\">Product Context:<\/b> Oxypro is an international brand-name formulation of extended-release oxycodone. The 30 mg strength represents a potent therapeutic unit dose utilized for established chronic pain management in opioid-tolerant or carefully evaluated patients.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"6,1,0\"><b data-path-to-node=\"6,1,0\" data-index-in-node=\"0\">Controlled Status:<\/b> Strictly regulated as a Prescription Only Medicine (POM) and a Schedule II Controlled Substance (or Class A \/ Schedule 2 Controlled Drug internationally) due to its extremely high potential for abuse, physical dependence, respiratory depression, and fatal overdose liability.<\/p>\n<\/li>\n<\/ul>\n<h2 data-path-to-node=\"7\">2. Mechanism of Action and Pharmacodynamics<\/h2>\n<p data-path-to-node=\"8\">Oxycodone exerts its primary analgesic and physiological effects through high-affinity interactions with central opioid receptors:<\/p>\n<ul data-path-to-node=\"9\">\n<li>\n<p data-path-to-node=\"9,0,0\"><b data-path-to-node=\"9,0,0\" data-index-in-node=\"0\"><span class=\"math-inline\" data-math=\"\\mu\" data-index-in-node=\"0\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord mathnormal\">\u03bc<\/span><\/span><\/span><\/span><\/span>-Opioid Receptor Agonism:<\/b> Acts as a primary agonist predominantly at <span class=\"math-inline\" data-math=\"\\mu\" data-index-in-node=\"72\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord mathnormal\">\u03bc<\/span><\/span><\/span><\/span><\/span>-opioid (<span class=\"math-inline\" data-math=\"\\text{MOR}\" data-index-in-node=\"84\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord text\"><span class=\"mord\">MOR<\/span><\/span><\/span><\/span><\/span><\/span>) receptors, and to a lesser extent at <span class=\"math-inline\" data-math=\"\\kappa\" data-index-in-node=\"133\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord mathnormal\">\u03ba<\/span><\/span><\/span><\/span><\/span> (<span class=\"math-inline\" data-math=\"\\text{KOR}\" data-index-in-node=\"141\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord text\"><span class=\"mord\">KOR<\/span><\/span><\/span><\/span><\/span><\/span>) receptors in the central nervous system and gastrointestinal tract.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"9,1,0\"><b data-path-to-node=\"9,1,0\" data-index-in-node=\"0\">Hyperpolarization &amp; Inhibition:<\/b> Activation of <span class=\"math-inline\" data-math=\"\\mu\" data-index-in-node=\"46\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord mathnormal\">\u03bc<\/span><\/span><\/span><\/span><\/span> receptors inhibits adenylate cyclase, closes voltage-gated calcium channels (reducing presynaptic neurotransmitter release), and opens potassium channels (hyperpolarizing postsynaptic neurons).<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"9,2,0\"><b data-path-to-node=\"9,2,0\" data-index-in-node=\"0\">Extended-Release Profile:<\/b> The modified-release matrix provides a slow, controlled dissolution and absorption profile designed to maintain therapeutic plasma concentrations over a 12-hour dosing interval.<\/p>\n<\/li>\n<\/ul>\n<h2 data-path-to-node=\"10\">3. Approved Clinical Indications and Dosing Scope<\/h2>\n<p data-path-to-node=\"11\">Licensing for oxycodone extended-release includes:<\/p>\n<ul data-path-to-node=\"12\">\n<li>\n<p data-path-to-node=\"12,0,0\"><b data-path-to-node=\"12,0,0\" data-index-in-node=\"0\">Severe Chronic Pain:<\/b> Long-term management of severe chronic pain requiring daily, continuous round-the-clock opioid analgesia when alternative treatment options are inadequate.<\/p>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"13\"><i data-path-to-node=\"13\" data-index-in-node=\"0\">Dosing &amp; Administration Regimen:<\/i><\/p>\n<ul data-path-to-node=\"14\">\n<li>\n<p data-path-to-node=\"14,0,0\"><b data-path-to-node=\"14,0,0\" data-index-in-node=\"0\">Individualized Titration:<\/b> Dosage must be individualized based on pain severity, prior opioid exposure, and patient age. The 30 mg strength is generally <b data-path-to-node=\"14,0,0\" data-index-in-node=\"152\">nicht<\/b> appropriate as an initial starting dose for opioid-naive patients due to the high risk of profound respiratory depression.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"14,1,0\"><b data-path-to-node=\"14,1,0\" data-index-in-node=\"0\">Tablet Integrity:<\/b> Extended-release tablets <b data-path-to-node=\"14,1,0\" data-index-in-node=\"43\">must be swallowed whole<\/b>. Never crush, chew, split, or dissolve oxypro 30 mg tablets, as tampering destroys the extended-release polymer matrix and causes immediate dose dumping of the entire active drug load, resulting in fatal overdose.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"14,2,0\"><b data-path-to-node=\"14,2,0\" data-index-in-node=\"0\">Dosing Frequency:<\/b> Administered orally on a fixed schedule, typically every 12 hours.<\/p>\n<\/li>\n<\/ul>\n<h2 data-path-to-node=\"15\">4. Pharmacokinetic Profile and Metabolic Fate<\/h2>\n<ul data-path-to-node=\"16\">\n<li>\n<p data-path-to-node=\"16,0,0\"><b data-path-to-node=\"16,0,0\" data-index-in-node=\"0\">Absorption:<\/b> Biphasic or prolonged absorption profile following oral administration, yielding high oral bioavailability (approximately 60% to 87%) due to lower first-pass metabolism compared to morphine. Peak plasma concentrations occur within 3 to 4 hours for extended-release preparations.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"16,1,0\"><b data-path-to-node=\"16,1,0\" data-index-in-node=\"0\">Distribution:<\/b> Rapidly distributes into skeletal muscle, liver, intestinal tract, lungs, and cerebrospinal fluid. Plasma protein binding is moderate (~45%). Crosses the blood-brain barrier and placenta.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"16,2,0\"><b data-path-to-node=\"16,2,0\" data-index-in-node=\"0\">Biotransformation:<\/b> Extensively metabolized in the liver via Cytochrome P450 enzymes (<b data-path-to-node=\"16,2,0\" data-index-in-node=\"85\">CYP3A4<\/b> und <b data-path-to-node=\"16,2,0\" data-index-in-node=\"96\">CYP2D6<\/b>):<\/p>\n<ul data-path-to-node=\"16,2,1\">\n<li>\n<p data-path-to-node=\"16,2,1,0,0\">Demethylated via CYP3A4 into <b data-path-to-node=\"16,2,1,0,0\" data-index-in-node=\"29\">noroxycodone<\/b> (major inactive metabolite).<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"16,2,1,1,0\">Demethylated via CYP2D6 into <b data-path-to-node=\"16,2,1,1,0\" data-index-in-node=\"29\">oxymorphone<\/b> (an active metabolite with potent <span class=\"math-inline\" data-math=\"\\mu\" data-index-in-node=\"75\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord mathnormal\">\u03bc<\/span><\/span><\/span><\/span><\/span>-opioid affinity, though present in low plasma concentrations).<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li>\n<p data-path-to-node=\"16,3,0\"><b data-path-to-node=\"16,3,0\" data-index-in-node=\"0\">Elimination:<\/b> Excreted primarily via the kidneys in urine as unchanged drug and inactive conjugates. The terminal elimination half-life of extended-release oxycodone averages 4 to 5 hours (though systemic release continues throughout the 12-hour dosing interval).<\/p>\n<\/li>\n<\/ul>\n<h2 data-path-to-node=\"17\">5. Physiological Effects and Adverse Event Spectrum<\/h2>\n<p data-path-to-node=\"18\">Oxycodone depresses central nervous system functions, suppresses respiratory drive, and inhibits gastrointestinal propulsion.<\/p>\n<h3 data-path-to-node=\"19\">Adverse Drug Reaction Spectrum<\/h3>\n<ul data-path-to-node=\"20\">\n<li>\n<p data-path-to-node=\"20,0,0\"><b data-path-to-node=\"20,0,0\" data-index-in-node=\"0\">Very Common (<span class=\"math-inline\" data-math=\"\\ge 1\/10\" data-index-in-node=\"13\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">\u2265<\/span><\/span><span class=\"base\"><span class=\"mord\">1\/10<\/span><\/span><\/span><\/span><\/span>):<\/b> Constipation, somnolence, dizziness, nausea, vomiting, headache, pruritus, asthenia.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"20,1,0\"><b data-path-to-node=\"20,1,0\" data-index-in-node=\"0\">Common (<span class=\"math-inline\" data-math=\"\\ge 1\/100\" data-index-in-node=\"8\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">\u2265<\/span><\/span><span class=\"base\"><span class=\"mord\">1\/100<\/span><\/span><\/span><\/span><\/span> to <span class=\"math-inline\" data-math=\"&lt;1\/10\" data-index-in-node=\"21\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">&lt;<\/span><\/span><span class=\"base\"><span class=\"mord\">1\/10<\/span><\/span><\/span><\/span><\/span>):<\/b> Dry mouth, abdominal pain, dyspepsia, diarrhea, sweating, anxiety, confusion, insomnia, urinary retention, rash.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"20,2,0\"><b data-path-to-node=\"20,2,0\" data-index-in-node=\"0\">Uncommon (<span class=\"math-inline\" data-math=\"\\ge 1\/1,000\" data-index-in-node=\"10\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">\u2265<\/span><\/span><span class=\"base\"><span class=\"mord\">1\/1<\/span><span class=\"mpunct\">,<\/span><span class=\"mord\">000<\/span><\/span><\/span><\/span><\/span> to <span class=\"math-inline\" data-math=\"&lt;1\/100\" data-index-in-node=\"25\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">&lt;<\/span><\/span><span class=\"base\"><span class=\"mord\">1\/100<\/span><\/span><\/span><\/span><\/span>):<\/b> Dysphoria, hallucinations, agitation, visual disturbances, bronchospasm, biliary tract spasm, flushing, orthostatic hypotension.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"20,3,0\"><b data-path-to-node=\"20,3,0\" data-index-in-node=\"0\">Rare \/ Severe (&lt;1\/1,000):<\/b> Severe respiratory depression, apnea, circulatory depression, anaphylactoid reactions, paralytic ileus, toxic megacolon, opioid-induced hyperalgesia, seizures.<\/p>\n<\/li>\n<\/ul>\n<h2 data-path-to-node=\"21\">6. Contraindications, Drug Interactions, and Clinical Precautions<\/h2>\n<h3 data-path-to-node=\"22\">Kontraindikationen<\/h3>\n<ul data-path-to-node=\"23\">\n<li>\n<p data-path-to-node=\"23,0,0\">Known hypersensitivity to oxycodone or other phenanthrene alkaloids.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"23,1,0\">Acute respiratory depression, severe chronic obstructive pulmonary disease (COPD), or acute asthma attacks.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"23,2,0\">Paralytic ileus or suspected surgical acute abdomen.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"23,3,0\">Moderate-to-severe hepatic impairment.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"23,4,0\">Concurrent administration with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of their cessation.<\/p>\n<\/li>\n<\/ul>\n<h3 data-path-to-node=\"24\">Key Drug Interactions<\/h3>\n<ul data-path-to-node=\"25\">\n<li>\n<p data-path-to-node=\"25,0,0\"><b data-path-to-node=\"25,0,0\" data-index-in-node=\"0\">CNS Depressants, Alcohol, &amp; Benzodiazepines:<\/b> Co-administration produces profound, synergistic central nervous system and respiratory depression, significantly elevating the risk of coma and fatal overdose.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"25,1,0\"><b data-path-to-node=\"25,1,0\" data-index-in-node=\"0\">Strong CYP3A4 Inhibitors or Inducers (e.g., Ketoconazole, Macrolide Antibiotics, Rifampicin):<\/b> Inhibitors can escalate oxycodone plasma concentrations and toxicity risks, whereas inducers can accelerate clearance and reduce analgesic efficacy.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"25,2,0\"><b data-path-to-node=\"25,2,0\" data-index-in-node=\"0\">Serotonergic Agents:<\/b> Co-administration with other serotonergic medications can increase the risk of serotonin syndrome.<\/p>\n<\/li>\n<\/ul>\n<h3 data-path-to-node=\"26\">Clinical Precautions and Monitoring<\/h3>\n<ul data-path-to-node=\"27\">\n<li>\n<p data-path-to-node=\"27,0,0\"><b data-path-to-node=\"27,0,0\" data-index-in-node=\"0\">Boxed Warning (Addiction, Abuse, and Misuse; Life-Threatening Respiratory Depression):<\/b> Oxypro exposes users to risks of addiction, abuse, and misuse, which can lead to overdose and death. Assess each patient&#8217;s risk prior to prescribing and monitor all patients regularly. Serious, life-threatening, or fatal respiratory depression can occur.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"27,1,0\"><b data-path-to-node=\"27,1,0\" data-index-in-node=\"0\">Neonatal Opioid Withdrawal Syndrome:<\/b> Long-term maternal use of oxycodone during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated.<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n    <div class=\"xs_social_share_widget xs_share_url after_content \t\tmain_content  wslu-style-1 wslu-share-box-shaped wslu-fill-colored wslu-none wslu-share-horizontal wslu-theme-font-no wslu-main_content\">\n\n\t\t\n        <ul>\n\t\t\t        <\/ul>\n    <\/div>","protected":false},"excerpt":{"rendered":"<p data-path-to-node=\"1\">Oxypro 30 mg is a high-strength modified-release oral tablet formulation containing oxycodone hydrochloride. As a potent opioid analgesic, it is indicated for the management of severe chronic pain requiring continuous, round-the-clock opioid therapy.<\/p>\n<h3 data-path-to-node=\"3\">\u00a0<\/h3>","protected":false},"featured_media":7719,"comment_status":"closed","ping_status":"closed","template":"","meta":{"postBodyCss":"","postBodyMargin":[],"postBodyPadding":[],"postBodyBackground":{"backgroundType":"classic","gradient":""}},"product_brand":[],"product_cat":[15],"product_tag":[220],"class_list":["post-7703","product","type-product","status-publish","has-post-thumbnail","product_cat-uncategorized","product_tag-oxypro-30mg","instock","shipping-taxable","purchasable","product-type-variable"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.5 (Yoast SEO v28.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Oxypro 30mg - British Pharmacy<\/title>\n<meta name=\"description\" content=\"Oxypro 30mg is a brand name for\u00a0oxycodone hydrochloride 30 mg, an immediate-release opioid analgesic used to manage moderate to severe pain.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/bristishpharmacy.co.uk\/de\/shop\/oxypro-30-mg\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Oxypro 30mg\" \/>\n<meta property=\"og:description\" content=\"Oxypro 30 mg is a high-strength modified-release oral tablet formulation containing oxycodone hydrochloride. 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