{"id":7736,"date":"2026-04-09T10:15:59","date_gmt":"2026-04-09T10:15:59","guid":{"rendered":"https:\/\/bristishpharmacy.co.uk\/?post_type=product&#038;p=7736"},"modified":"2026-09-17T19:16:27","modified_gmt":"2026-09-17T19:16:27","slug":"co-codamol-15-500-mg","status":"publish","type":"product","link":"https:\/\/bristishpharmacy.co.uk\/de\/shop\/co-codamol-15-500-mg\/","title":{"rendered":"Co-Codamol 15\/500 mg"},"content":{"rendered":"<h1>\u00a0<\/h1>\n<div class=\"container\">\n<div id=\"model-response-message-contentr_c4a2939729fe0d64\" class=\"markdown markdown-main-panel md-content enable-luminous-fast-follows enable-updated-hr-color stronger tutor-markdown-rendering\" dir=\"ltr\" aria-live=\"polite\">\n<h3 data-path-to-node=\"3\">Clinical Monograph: Co-Codamol 15\/500 mg<\/h3>\n<h2 data-path-to-node=\"4\">1. Classification and Chemical Overview<\/h2>\n<p data-path-to-node=\"5\">Co-Codamol combines two active pharmaceutical ingredients with distinct analgesic mechanisms:<\/p>\n<ul data-path-to-node=\"6\">\n<li>\n<p data-path-to-node=\"6,0,0\"><b data-path-to-node=\"6,0,0\" data-index-in-node=\"0\">Codeine Phosphate:<\/b> A semi-synthetic phenanthrene-derivative opioid alkaloid acting as a central analgesic and antitussive.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"6,1,0\"><b data-path-to-node=\"6,1,0\" data-index-in-node=\"0\">Paracetamol (Acetaminophen):<\/b> A centrally acting analgesic and antipyretic agent derived from p-aminophenol.<\/p>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"7\">Under the Anatomical Therapeutic Chemical (ATC) system, this combination is indexed under N02BE51 (Paracetamol, combinations excl. psycholeptics).<\/p>\n<ul data-path-to-node=\"8\">\n<li>\n<p data-path-to-node=\"8,0,0\"><b data-path-to-node=\"8,0,0\" data-index-in-node=\"0\">Product Context:<\/b> The 15\/500 mg strength represents a low-to-moderate strength formulation (often available over-the-counter in certain jurisdictions under strict pharmacist supervision or via prescription internationally).<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"8,1,0\"><b data-path-to-node=\"8,1,0\" data-index-in-node=\"0\">Controlled Status:<\/b> Regulated as a Prescription Only Medicine (POM) or pharmacy-controlled medication depending on regional jurisdiction. Codeine content confers risks of physical dependence, tolerance, and misuse liability with prolonged use.<\/p>\n<\/li>\n<\/ul>\n<h2 data-path-to-node=\"9\">2. Mechanism of Action and Pharmacodynamics<\/h2>\n<p data-path-to-node=\"10\">The combination utilizes synergistic central and peripheral pathways to control pain:<\/p>\n<ul data-path-to-node=\"11\">\n<li>\n<p data-path-to-node=\"11,0,0\"><b data-path-to-node=\"11,0,0\" data-index-in-node=\"0\">Paracetamol Action:<\/b> Inhibits central prostaglandin synthesis (via action on cyclooxygenase enzymes COX-2 and COX-3) to elevate the pain threshold and reduce fever.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"11,1,0\"><b data-path-to-node=\"11,1,0\" data-index-in-node=\"0\">Codeine Opioid Agonism:<\/b> Codeine acts partially as a prodrug; hepatic cytochrome P450 enzymes (specifically <b data-path-to-node=\"11,1,0\" data-index-in-node=\"107\">CYP2D6<\/b>) metabolize a fraction of codeine into active morphine, which binds to central <span class=\"math-inline\" data-math=\"\\mu\" data-index-in-node=\"193\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord mathnormal\">\u03bc<\/span><\/span><\/span><\/span><\/span>-opioid (<span class=\"math-inline\" data-math=\"\\text{MOR}\" data-index-in-node=\"205\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord text\"><span class=\"mord\">MOR<\/span><\/span><\/span><\/span><\/span><\/span>) receptors to modify nociceptive signaling.<\/p>\n<\/li>\n<\/ul>\n<h2 data-path-to-node=\"12\">3. Approved Clinical Indications and Dosing Scope<\/h2>\n<p data-path-to-node=\"13\">Licensing for Co-Codamol 15\/500 mg includes:<\/p>\n<ul data-path-to-node=\"14\">\n<li>\n<p data-path-to-node=\"14,0,0\"><b data-path-to-node=\"14,0,0\" data-index-in-node=\"0\">Acute Moderate Pain:<\/b> Short-term management of acute moderate pain conditions (such as tension headaches, musculoskeletal aches, dental pain, or dysmenorrhea) not relieved by paracetamol, ibuprofen, or aspirin alone.<\/p>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"15\"><i data-path-to-node=\"15\" data-index-in-node=\"0\">Dosing &amp; Administration Parameters:<\/i><\/p>\n<ul data-path-to-node=\"16\">\n<li>\n<p data-path-to-node=\"16,0,0\"><b data-path-to-node=\"16,0,0\" data-index-in-node=\"0\">Adult Dosing:<\/b> Typically 1 to 2 tablets taken orally every 4 to 6 hours as needed for pain.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"16,1,0\"><b data-path-to-node=\"16,1,0\" data-index-in-node=\"0\">Maximum Daily Limits:<\/b> <b data-path-to-node=\"16,1,0\" data-index-in-node=\"22\">Strictly do not exceed 8 tablets in any 24-hour period<\/b> due to the cumulative hepatotoxic risk of paracetamol (maximum daily paracetamol dose is 4,000 mg).<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"16,2,0\"><b data-path-to-node=\"16,2,0\" data-index-in-node=\"0\">Duration Restrictions:<\/b> Use must be restricted to short-term acute treatment (typically not exceeding 3 consecutive days without medical re-evaluation) to prevent the development of opioid dependence or medication-overuse headaches.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"16,3,0\"><b data-path-to-node=\"16,3,0\" data-index-in-node=\"0\">Exclusions:<\/b> Contraindicated in children under 12 years of age, breastfeeding women, and known CYP2D6 ultra-rapid metabolizers.<\/p>\n<\/li>\n<\/ul>\n<h2 data-path-to-node=\"17\">4. Pharmacokinetic Profile and Metabolic Fate<\/h2>\n<ul data-path-to-node=\"18\">\n<li>\n<p data-path-to-node=\"18,0,0\"><b data-path-to-node=\"18,0,0\" data-index-in-node=\"0\">Absorption:<\/b> Both active ingredients are rapidly and well absorbed from the gastrointestinal tract following oral administration, with peak plasma concentrations (<span class=\"math-inline\" data-math=\"C_{max}\" data-index-in-node=\"162\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord\"><span class=\"mord mathnormal\">C<\/span><span class=\"msupsub\"><span class=\"vlist-t vlist-t2\"><span class=\"vlist-r\"><span class=\"vlist\"><span class=\"\"><span class=\"sizing reset-size6 size3 mtight\"><span class=\"mord mtight\"><span class=\"mord mathnormal mtight\">ma<\/span><span class=\"mord mathnormal mtight\">x<\/span><\/span><\/span><\/span><\/span><span class=\"vlist-s\">\u200b<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span>) occurring within 30 to 60 minutes.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"18,1,0\"><b data-path-to-node=\"18,1,0\" data-index-in-node=\"0\">Distribution:<\/b> Paracetamol distributes into most body tissues and crosses the placenta. Codeine exhibits low-to-moderate plasma protein binding and readily crosses the blood-brain barrier.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"18,2,0\"><b data-path-to-node=\"18,2,0\" data-index-in-node=\"0\">Biotransformation:<\/b><\/p>\n<ul data-path-to-node=\"18,2,1\">\n<li>\n<p data-path-to-node=\"18,2,1,0,0\">Paracetamol is metabolized primarily in the liver via glucuronidation and sulfation, with a small fraction metabolized via CYP2E1 into the toxic intermediate <b data-path-to-node=\"18,2,1,0,0\" data-index-in-node=\"158\">NAPQI<\/b> (which is detoxified by glutathione).<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"18,2,1,1,0\">Codeine undergoes hepatic O-demethylation via <b data-path-to-node=\"18,2,1,1,0\" data-index-in-node=\"46\">CYP2D6<\/b> into morphine and N-demethylation via <b data-path-to-node=\"18,2,1,1,0\" data-index-in-node=\"91\">CYP3A4<\/b> into norcodeine.<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li>\n<p data-path-to-node=\"18,3,0\"><b data-path-to-node=\"18,3,0\" data-index-in-node=\"0\">Elimination:<\/b> Excreted primarily via the kidneys in urine as inactive glucuronide and sulfate metabolites. The elimination half-life for both components averages 2 to 4 hours.<\/p>\n<\/li>\n<\/ul>\n<h2 data-path-to-node=\"19\">5. Physiological Effects and Adverse Event Spectrum<\/h2>\n<p data-path-to-node=\"20\">Co-Codamol alters central pain processing, slows gastrointestinal motility, and exerts hepatic metabolic demands.<\/p>\n<h3 data-path-to-node=\"21\">Adverse Drug Reaction Spectrum<\/h3>\n<ul data-path-to-node=\"22\">\n<li>\n<p data-path-to-node=\"22,0,0\"><b data-path-to-node=\"22,0,0\" data-index-in-node=\"0\">Common (<span class=\"math-inline\" data-math=\"\\ge 1\/100\" data-index-in-node=\"8\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">\u2265<\/span><\/span><span class=\"base\"><span class=\"mord\">1\/100<\/span><\/span><\/span><\/span><\/span> to <span class=\"math-inline\" data-math=\"&lt;1\/10\" data-index-in-node=\"21\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">&lt;<\/span><\/span><span class=\"base\"><span class=\"mord\">1\/10<\/span><\/span><\/span><\/span><\/span>):<\/b> Constipation, nausea, drowsiness, dizziness, lightheadedness, somnolence.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"22,1,0\"><b data-path-to-node=\"22,1,0\" data-index-in-node=\"0\">Uncommon (<span class=\"math-inline\" data-math=\"\\ge 1\/1,000\" data-index-in-node=\"10\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">\u2265<\/span><\/span><span class=\"base\"><span class=\"mord\">1\/1<\/span><span class=\"mpunct\">,<\/span><span class=\"mord\">000<\/span><\/span><\/span><\/span><\/span> to <span class=\"math-inline\" data-math=\"&lt;1\/100\" data-index-in-node=\"25\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">&lt;<\/span><\/span><span class=\"base\"><span class=\"mord\">1\/100<\/span><\/span><\/span><\/span><\/span>):<\/b> Dry mouth, abdominal discomfort, pruritus, skin rashes, sweating, urinary retention.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"22,2,0\"><b data-path-to-node=\"22,2,0\" data-index-in-node=\"0\">Rare \/ Severe (&lt;1\/1,000):<\/b> Severe hepatotoxicity or acute liver failure (from paracetamol overdose), respiratory depression, severe allergic reactions (anaphylaxis, Stevens-Johnson syndrome), paralytic ileus, and dependence\/withdrawal symptoms upon chronic cessation.<\/p>\n<\/li>\n<\/ul>\n<h2 data-path-to-node=\"23\">6. Contraindications, Drug Interactions, and Clinical Precautions<\/h2>\n<h3 data-path-to-node=\"24\">Kontraindikationen<\/h3>\n<ul data-path-to-node=\"25\">\n<li>\n<p data-path-to-node=\"25,0,0\">Known hypersensitivity to paracetamol, codeine, or formulation excipients.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"25,1,0\">Acute hepatic impairment or severe hepatocellular disease.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"25,2,0\">Acute respiratory depression, chronic obstructive pulmonary disease (COPD) with severe respiratory reserve depletion, or acute asthma attacks.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"25,3,0\">Pediatric patients under 12 years of age or post-tonsillectomy\/adenoidectomy.<\/p>\n<\/li>\n<\/ul>\n<h3 data-path-to-node=\"26\">Key Drug Interactions<\/h3>\n<ul data-path-to-node=\"27\">\n<li>\n<p data-path-to-node=\"27,0,0\"><b data-path-to-node=\"27,0,0\" data-index-in-node=\"0\">Alcohol &amp; Hepatotoxic Agents:<\/b> Chronic or excessive alcohol consumption co-administered with paracetamol drastically increases the risk of severe, fatal hepatotoxicity due to glutathione depletion and enhanced NAPQI formation.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"27,1,0\"><b data-path-to-node=\"27,1,0\" data-index-in-node=\"0\">CNS Depressants, Sedatives, &amp; Alcohol:<\/b> Co-ingestion with alcohol, benzodiazepines, or other central depressants produces additive central nervous system and respiratory depression.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"27,2,0\"><b data-path-to-node=\"27,2,0\" data-index-in-node=\"0\">CYP2D6 Inhibitors (e.g., Quinidine):<\/b> Can inhibit the metabolic conversion of codeine to morphine, reducing the analgesic efficacy of the opioid component.<\/p>\n<\/li>\n<\/ul>\n<h3 data-path-to-node=\"28\">Clinical Precautions and Monitoring<\/h3>\n<ul data-path-to-node=\"29\">\n<li>\n<p data-path-to-node=\"29,0,0\"><b data-path-to-node=\"29,0,0\" data-index-in-node=\"0\">Paracetamol Overdose Risk:<\/b> Patients must be strictly cautioned against concurrent use of other over-the-counter or prescription medications containing paracetamol (such as cold and flu remedies), as accidental paracetamol overdose causes severe, irreversible liver necrosis.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"29,1,0\"><b data-path-to-node=\"29,1,0\" data-index-in-node=\"0\">Opioid Dependency &amp; Abuse:<\/b> Due to the codeine content, prolonged use can result in physical dependence, tolerance, and psychological addiction. Taper gradually if discontinued after regular use.<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n    <div class=\"xs_social_share_widget xs_share_url after_content \t\tmain_content  wslu-style-1 wslu-share-box-shaped wslu-fill-colored wslu-none wslu-share-horizontal wslu-theme-font-no wslu-main_content\">\n\n\t\t\n        <ul>\n\t\t\t        <\/ul>\n    <\/div>","protected":false},"excerpt":{"rendered":"<p data-path-to-node=\"1\">Co-Codamol 15\/500 mg is an oral combination analgesic tablet containing 15 mg of codeine phosphate and 500 mg of paracetamol (acetaminophen). It is indicated for the short-term management of moderate acute pain that is unresponsive to non-opioid analgesics alone.<\/p>\n<h3 data-path-to-node=\"3\">\u00a0<\/h3>","protected":false},"featured_media":7749,"comment_status":"closed","ping_status":"closed","template":"","meta":{"postBodyCss":"","postBodyMargin":[],"postBodyPadding":[],"postBodyBackground":{"backgroundType":"classic","gradient":""}},"product_brand":[],"product_cat":[108],"product_tag":[211],"class_list":["post-7736","product","type-product","status-publish","has-post-thumbnail","product_cat-pain-relief","product_tag-co-codamol-15-500mg","instock","shipping-taxable","purchasable","product-type-variable"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.5 (Yoast SEO v28.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Co-Codamol 15\/500mg - British Pharmacy<\/title>\n<meta name=\"description\" content=\"Co-Codamol 15\/500mg is a a non-opioid pain reliever and fever reducer that inhibits prostaglandin synthesis in the central nervous system\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/bristishpharmacy.co.uk\/de\/shop\/co-codamol-15-500-mg\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Co-Codamol 15\/500mg\" \/>\n<meta property=\"og:description\" content=\"Co-Codamol 15\/500 mg is an oral combination analgesic tablet containing 15 mg of codeine phosphate and 500 mg of paracetamol (acetaminophen). It is indicated for the short-term management of moderate acute pain that is unresponsive to non-opioid analgesics alone.\u00a0\" \/>\n<meta property=\"og:url\" content=\"https:\/\/bristishpharmacy.co.uk\/de\/shop\/co-codamol-15-500-mg\/\" \/>\n<meta property=\"og:site_name\" content=\"British Pharmacy\" \/>\n<meta property=\"article:modified_time\" content=\"2026-09-17T19:16:27+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/bristishpharmacy.co.uk\/wp-content\/uploads\/2026\/04\/photo_5096273778597104775_x.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"500\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/bristishpharmacy.co.uk\\\/shop\\\/co-codamol-15-500mg\\\/\",\"url\":\"https:\\\/\\\/bristishpharmacy.co.uk\\\/shop\\\/co-codamol-15-500mg\\\/\",\"name\":\"Co-Codamol 15\\\/500mg - British Pharmacy\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/bristishpharmacy.co.uk\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/bristishpharmacy.co.uk\\\/shop\\\/co-codamol-15-500mg\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/bristishpharmacy.co.uk\\\/shop\\\/co-codamol-15-500mg\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/bristishpharmacy.co.uk\\\/wp-content\\\/uploads\\\/2026\\\/04\\\/photo_5096273778597104775_x.jpg\",\"datePublished\":\"2026-04-09T10:15:59+00:00\",\"dateModified\":\"2026-09-17T19:16:27+00:00\",\"description\":\"Co-Codamol 15\\\/500mg is a a non-opioid pain reliever and fever reducer that inhibits prostaglandin synthesis in the central nervous system\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/bristishpharmacy.co.uk\\\/shop\\\/co-codamol-15-500mg\\\/#breadcrumb\"},\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/bristishpharmacy.co.uk\\\/shop\\\/co-codamol-15-500mg\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\\\/\\\/bristishpharmacy.co.uk\\\/shop\\\/co-codamol-15-500mg\\\/#primaryimage\",\"url\":\"https:\\\/\\\/bristishpharmacy.co.uk\\\/wp-content\\\/uploads\\\/2026\\\/04\\\/photo_5096273778597104775_x.jpg\",\"contentUrl\":\"https:\\\/\\\/bristishpharmacy.co.uk\\\/wp-content\\\/uploads\\\/2026\\\/04\\\/photo_5096273778597104775_x.jpg\",\"width\":500,\"height\":500,\"caption\":\"Co-Codamol 15\\\/500mg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/bristishpharmacy.co.uk\\\/shop\\\/co-codamol-15-500mg\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/bristishpharmacy.co.uk\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Shop\",\"item\":\"https:\\\/\\\/bristishpharmacy.co.uk\\\/shop\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Co-Codamol 15\\\/500mg\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/bristishpharmacy.co.uk\\\/#website\",\"url\":\"https:\\\/\\\/bristishpharmacy.co.uk\\\/\",\"name\":\"British Pharmacy\",\"description\":\"Order Medication &amp; 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