{"id":6827,"date":"2025-12-09T23:02:26","date_gmt":"2025-12-09T23:02:26","guid":{"rendered":"https:\/\/bristishpharmacy.co.uk\/?post_type=product&#038;p=6827"},"modified":"2026-09-16T10:28:24","modified_gmt":"2026-09-16T10:28:24","slug":"oxycodone-hcl-80mg","status":"publish","type":"product","link":"https:\/\/bristishpharmacy.co.uk\/it\/shop\/oxycodone-hcl-80mg\/","title":{"rendered":"Ossicodone HCl 80mg"},"content":{"rendered":"<div class=\"container\">\n<div id=\"model-response-message-contentr_626d510b6fb8b0fb\" class=\"markdown markdown-main-panel md-content enable-luminous-fast-follows enable-updated-hr-color stronger tutor-markdown-rendering\" dir=\"ltr\" aria-live=\"polite\">\n<h3 data-path-to-node=\"3\">Clinical Monograph: Oxycodone HCl 80 mg<\/h3>\n<div class=\"attachment-container search-images\">\n<div class=\"image-container spark-licensed-center hide-from-message-actions ng-star-inserted\" data-full-size-image-uri=\"https:\/\/tajpharma.in\/wp-content\/uploads\/cache\/images\/Oxycodone_ER_Tablet_80mg_Manufacturing_Companies_India-scaled\/Oxycodone_ER_Tablet_80mg_Manufacturing_Companies_India-scaled-660643153.jpg\">\n<div class=\"overlay-container hero-overlay-container ng-star-inserted\"><button class=\"image-button ng-star-inserted\"><img fetchpriority=\"high\" decoding=\"async\" class=\"spark-licensed-landscape hero-image loaded\" src=\"https:\/\/encrypted-tbn0.gstatic.com\/images?q=tbn:ANd9GcTpDyJGe4GumVZdxw09WoqoQJYxBNpnicwbPRA6LanXKQ37TdlozbXccXI&amp;s=10\" alt=\"Oxycodone HCl 80 mg extended-release packaging, AI generated\" width=\"559\" height=\"549\" \/><\/button><\/p>\n<div class=\"hero-caption-row ng-star-inserted\">\n<div class=\"caption gds-extended-caption hero-caption ng-star-inserted\" aria-hidden=\"true\">Oxycodone HCl 80 mg extended-release packaging. <span class=\"ng-star-inserted\">Source: Taj Pharma India<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<h2 data-path-to-node=\"5\">1. Classification and Chemical Overview<\/h2>\n<p data-path-to-node=\"6\">Oxycodone is a semi-synthetic, pure opioid agonist derivative of the morphinan alkaloid thebaine. Chemically designated as (5$\\alpha$)-4,5-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one hydrochloride, it belongs to the phenanthrene class of opioids. Under the Anatomical Therapeutic Chemical (ATC) classification system, oxycodone is indexed under N02AA05.<\/p>\n<p data-path-to-node=\"7\">Oxycodone HCl 80 mg is formulated as modified-release (prolonged-release \/ extended-release) oral tablets containing 80 mg oxycodone hydrochloride (equivalent to 71.72 mg free oxycodone base). Internationally, oxycodone is classified as a strictly controlled substance (e.g., Schedule II in the US; Class B \/ Schedule 2 Controlled Drug in the UK) and is available strictly as a Prescription Only Medicine (POM). The 80 mg single-tablet strength represents a high-dose unit intended solely for opioid-tolerant individuals.<\/p>\n<h2 data-path-to-node=\"8\">2. Mechanism of Action and Pharmacodynamics<\/h2>\n<p data-path-to-node=\"9\">Oxycodone acts as a full agonist at central and peripheral opioid receptors, displaying primary selectivity for <span class=\"math-inline\" data-math=\"\\mu\" data-index-in-node=\"112\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord mathnormal\">\u03bc<\/span><\/span><\/span><\/span><\/span>-opioid receptors alongside minor interactions at <span class=\"math-inline\" data-math=\"\\kappa\" data-index-in-node=\"165\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord mathnormal\">\u03ba<\/span><\/span><\/span><\/span><\/span>&#8211; and <span class=\"math-inline\" data-math=\"\\delta\" data-index-in-node=\"177\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord mathnormal\">\u03b4<\/span><\/span><\/span><\/span><\/span>-opioid receptors:<\/p>\n<ul data-path-to-node=\"10\">\n<li>\n<p data-path-to-node=\"10,0,0\"><b data-path-to-node=\"10,0,0\" data-index-in-node=\"0\"><span class=\"math-inline\" data-math=\"\\mu\" data-index-in-node=\"0\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord mathnormal\">\u03bc<\/span><\/span><\/span><\/span><\/span>-Opioid Receptor Activation:<\/b> Binds to G-protein-coupled <span class=\"math-inline\" data-math=\"\\mu\" data-index-in-node=\"59\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord mathnormal\">\u03bc<\/span><\/span><\/span><\/span><\/span>-receptors located on presynaptic and postsynaptic neuronal membranes throughout the central nervous system (brainstem, locus coeruleus, periaqueductal gray) and spinal cord (dorsal horn).<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"10,1,0\"><b data-path-to-node=\"10,1,0\" data-index-in-node=\"0\">Signal Transduction:<\/b> Inhibits adenylyl cyclase activity, decreases intracellular cyclic AMP (<span class=\"math-inline\" data-math=\"\\text{cAMP}\" data-index-in-node=\"93\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord text\"><span class=\"mord\">cAMP<\/span><\/span><\/span><\/span><\/span><\/span>), hyperpolarizes neuronal membranes by opening inwardly rectifying potassium channels, and inhibits voltage-gated calcium channels.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"10,2,0\"><b data-path-to-node=\"10,2,0\" data-index-in-node=\"0\">Analgesic Transmission:<\/b> Suppresses presynaptic release of nociceptive neurotransmitters (substance P, glutamate, CGRP), attenuating pain impulse conduction along spinothalamic pathways and modifying central perception of pain.<\/p>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"11\">Additional systemic pharmacodynamic actions include dose-dependent respiratory center depression, sedation, miosis, cough suppression, gastrointestinal smooth muscle tone elevation (leading to delayed transit), and biliary sphincter spasm.<\/p>\n<h2 data-path-to-node=\"12\">3. Approved Clinical Indications and Therapeutic Scope<\/h2>\n<p data-path-to-node=\"13\">Licensing for Oxycodone HCl 80 mg includes:<\/p>\n<ul data-path-to-node=\"14\">\n<li>\n<p data-path-to-node=\"14,0,0\"><b data-path-to-node=\"14,0,0\" data-index-in-node=\"0\">Severe Chronic Pain Management:<\/b> Management of severe, refractory pain requiring continuous, round-the-clock opioid administration for an extended period (e.g., advanced cancer-related pain or severe chronic non-cancer pain unresponsive to lower opioid dosages).<\/p>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"15\"><i data-path-to-node=\"15\" data-index-in-node=\"0\">Formulation Dynamics &amp; Dosing Regimens:<\/i><\/p>\n<ul data-path-to-node=\"16\">\n<li>\n<p data-path-to-node=\"16,0,0\"><b data-path-to-node=\"16,0,0\" data-index-in-node=\"0\">Modified-Release \/ Prolonged-Release (MR) 80 mg:<\/b> Formulated for continuous 12-hour drug delivery. Administered twice daily (every 12 hours) for stable chronic pain control.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"16,1,0\"><b data-path-to-node=\"16,1,0\" data-index-in-node=\"0\">Strict Safety Mandate:<\/b> <i data-path-to-node=\"16,1,0\" data-index-in-node=\"23\">Modified-release 80 mg tablets must be swallowed whole and never crushed, chewed, split, or dissolved. Disrupting the controlled-release delivery matrix causes rapid drug release (&#8220;dose dumping&#8221;), leading to acute toxicity, massive overdose, respiratory arrest, and death.<\/i><\/p>\n<\/li>\n<\/ul>\n<h2 data-path-to-node=\"17\">4. Pharmacokinetic Profile and Metabolic Fate<\/h2>\n<ul data-path-to-node=\"18\">\n<li>\n<p data-path-to-node=\"18,0,0\"><b data-path-to-node=\"18,0,0\" data-index-in-node=\"0\">Absorption:<\/b> Extended-release matrices provide continuous, slow absorption over 12 hours. Absolute oral bioavailability is high (60% to 87%) due to low hepatic first-pass metabolism. Peak plasma concentration (<span class=\"math-inline\" data-math=\"C_{max}\" data-index-in-node=\"209\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord\"><span class=\"mord mathnormal\">C<\/span><span class=\"msupsub\"><span class=\"vlist-t vlist-t2\"><span class=\"vlist-r\"><span class=\"vlist\"><span class=\"\"><span class=\"sizing reset-size6 size3 mtight\"><span class=\"mord mtight\"><span class=\"mord mathnormal mtight\">ma<\/span><span class=\"mord mathnormal mtight\">x<\/span><\/span><\/span><\/span><\/span><span class=\"vlist-s\">\u200b<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span>) occurs within 3 to 5 hours (<span class=\"math-inline\" data-math=\"T_{max}\" data-index-in-node=\"246\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord\"><span class=\"mord mathnormal\">T<\/span><span class=\"msupsub\"><span class=\"vlist-t vlist-t2\"><span class=\"vlist-r\"><span class=\"vlist\"><span class=\"\"><span class=\"sizing reset-size6 size3 mtight\"><span class=\"mord mtight\"><span class=\"mord mathnormal mtight\">ma<\/span><span class=\"mord mathnormal mtight\">x<\/span><\/span><\/span><\/span><\/span><span class=\"vlist-s\">\u200b<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span>) post-ingestion.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"18,1,0\"><b data-path-to-node=\"18,1,0\" data-index-in-node=\"0\">Distribution:<\/b> Extensively distributed throughout body tissues following systemic uptake (<span class=\"math-inline\" data-math=\"V_d \\approx 2.6\\text{ L\/kg}\" data-index-in-node=\"89\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord\"><span class=\"mord mathnormal\">V<\/span><span class=\"msupsub\"><span class=\"vlist-t vlist-t2\"><span class=\"vlist-r\"><span class=\"vlist\"><span class=\"\"><span class=\"sizing reset-size6 size3 mtight\"><span class=\"mord mathnormal mtight\">d<\/span><\/span><\/span><\/span><span class=\"vlist-s\">\u200b<\/span><\/span><\/span><\/span><\/span><span class=\"mrel\">\u2248<\/span><\/span><span class=\"base\"><span class=\"mord\">2.6<\/span><span class=\"mord text\"><span class=\"mord\">\u00a0L\/kg<\/span><\/span><\/span><\/span><\/span><\/span>). Plasma protein binding ranges between 38% and 45% (primarily to human serum albumin). Oxycodone crosses the blood-brain barrier and placenta, and is excreted in human breast milk.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"18,2,0\"><b data-path-to-node=\"18,2,0\" data-index-in-node=\"0\">Biotransformation:<\/b> Extensively metabolised in the liver via two primary Cytochrome P450 pathways:<\/p>\n<ul data-path-to-node=\"18,2,1\">\n<li>\n<p data-path-to-node=\"18,2,1,0,0\"><b data-path-to-node=\"18,2,1,0,0\" data-index-in-node=\"0\">CYP3A4 Pathway (Major):<\/b> <span class=\"math-inline\" data-math=\"N\" data-index-in-node=\"24\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord mathnormal\">N<\/span><\/span><\/span><\/span><\/span>-demethylation to <b data-path-to-node=\"18,2,1,0,0\" data-index-in-node=\"43\">noroxycodone<\/b> (inactive\/weakly active circulating metabolite).<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"18,2,1,1,0\"><b data-path-to-node=\"18,2,1,1,0\" data-index-in-node=\"0\">CYP2D6 Pathway (Minor):<\/b> <span class=\"math-inline\" data-math=\"O\" data-index-in-node=\"24\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord mathnormal\">O<\/span><\/span><\/span><\/span><\/span>-demethylation to <b data-path-to-node=\"18,2,1,1,0\" data-index-in-node=\"43\">oxymorphone<\/b> (potent active opioid agonist).<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"18,2,1,2,0\">Metabolites undergo subsequent Phase II glucuronide conjugation.<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li>\n<p data-path-to-node=\"18,3,0\"><b data-path-to-node=\"18,3,0\" data-index-in-node=\"0\">Elimination:<\/b> Excreted predominantly via the kidneys in urine as conjugated metabolites and unchanged parent compound (&lt; 10%). Elimination half-life (<span class=\"math-inline\" data-math=\"t_{1\/2}\" data-index-in-node=\"149\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord\"><span class=\"mord mathnormal\">t<\/span><span class=\"msupsub\"><span class=\"vlist-t vlist-t2\"><span class=\"vlist-r\"><span class=\"vlist\"><span class=\"\"><span class=\"sizing reset-size6 size3 mtight\"><span class=\"mord mtight\">1\/2<\/span><\/span><\/span><\/span><span class=\"vlist-s\">\u200b<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span>) is approximately 8 hours for modified-release formulations.<\/p>\n<\/li>\n<\/ul>\n<h2 data-path-to-node=\"19\">5. Physiological Effects and Adverse Event Spectrum<\/h2>\n<p data-path-to-node=\"20\">Oxycodone depresses central nervous system processing and slows peripheral gastrointestinal motility.<\/p>\n<h3 data-path-to-node=\"21\">Adverse Drug Reaction Spectrum<\/h3>\n<ul data-path-to-node=\"22\">\n<li>\n<p data-path-to-node=\"22,0,0\"><b data-path-to-node=\"22,0,0\" data-index-in-node=\"0\">Very Common (<span class=\"math-inline\" data-math=\"\\ge 1\/10\" data-index-in-node=\"13\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">\u2265<\/span><\/span><span class=\"base\"><span class=\"mord\">1\/10<\/span><\/span><\/span><\/span><\/span>):<\/b> Constipation, nausea, vomiting, somnolence, dizziness, headache, pruritus.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"22,1,0\"><b data-path-to-node=\"22,1,0\" data-index-in-node=\"0\">Common (<span class=\"math-inline\" data-math=\"\\ge 1\/100\" data-index-in-node=\"8\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">\u2265<\/span><\/span><span class=\"base\"><span class=\"mord\">1\/100<\/span><\/span><\/span><\/span><\/span> to <span class=\"math-inline\" data-math=\"&lt;1\/10\" data-index-in-node=\"21\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">&lt;<\/span><\/span><span class=\"base\"><span class=\"mord\">1\/10<\/span><\/span><\/span><\/span><\/span>):<\/b> Dry mouth, anorexia, abdominal pain, dyspepsia, asthenia\/fatigue, confusion, anxiety, depression, insomnia, hyperhidrosis, rash.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"22,2,0\"><b data-path-to-node=\"22,2,0\" data-index-in-node=\"0\">Uncommon (<span class=\"math-inline\" data-math=\"\\ge 1\/1,000\" data-index-in-node=\"10\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">\u2265<\/span><\/span><span class=\"base\"><span class=\"mord\">1\/1<\/span><span class=\"mpunct\">,<\/span><span class=\"mord\">000<\/span><\/span><\/span><\/span><\/span> to <span class=\"math-inline\" data-math=\"&lt;1\/100\" data-index-in-node=\"25\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">&lt;<\/span><\/span><span class=\"base\"><span class=\"mord\">1\/100<\/span><\/span><\/span><\/span><\/span>):<\/b> Respiratory depression, profound sedation, miosis, urinary retention, hallucinations, agitation, euphoria, orthostatic hypotension, physical dependence\/withdrawal symptoms.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"22,3,0\"><b data-path-to-node=\"22,3,0\" data-index-in-node=\"0\">Rare \/ Very Rare (&lt;1\/1,000):<\/b> Anaphylactic reactions, paralytic ileus, seizures, opioid-induced hyperalgesia, adrenal insufficiency.<\/p>\n<\/li>\n<\/ul>\n<h2 data-path-to-node=\"23\">6. Contraindications, Drug Interactions, and Clinical Precautions<\/h2>\n<h3 data-path-to-node=\"24\">Controindicazioni<\/h3>\n<ul data-path-to-node=\"25\">\n<li>\n<p data-path-to-node=\"25,0,0\"><b data-path-to-node=\"25,0,0\" data-index-in-node=\"0\">Opioid-Na\u00efve Patients:<\/b> Absolutely contraindicated in non-opioid-tolerant individuals. Administering an 80 mg single dose to an opioid-na\u00efve patient can precipitate severe, fatal respiratory depression.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"25,1,0\">Known hypersensitivity to oxycodone or formulation excipients.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"25,2,0\">Severe respiratory depression with hypoxia or hypercapnia.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"25,3,0\">Severe chronic obstructive pulmonary disease (COPD) or acute severe bronchial asthma.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"25,4,0\">Paralytic ileus or acute abdomen.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"25,5,0\">Moderate to severe hepatic impairment.<\/p>\n<\/li>\n<\/ul>\n<h3 data-path-to-node=\"26\">Key Drug Interactions<\/h3>\n<ul data-path-to-node=\"27\">\n<li>\n<p data-path-to-node=\"27,0,0\"><b data-path-to-node=\"27,0,0\" data-index-in-node=\"0\">CYP3A4 Inhibitors (e.g., Ketoconazole, Clarithromycin, Ritonavir, Grapefruit Juice):<\/b> Significantly increase plasma oxycodone concentrations, drastically elevating the risk of fatal respiratory depression.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"27,1,0\"><b data-path-to-node=\"27,1,0\" data-index-in-node=\"0\">CYP3A4 Inducers (e.g., Rifampicin, Carbamazepine, St. John&#8217;s Wort):<\/b> Accelerate clearance, reducing efficacy and potentially precipitating withdrawal in dependent patients.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"27,2,0\"><b data-path-to-node=\"27,2,0\" data-index-in-node=\"0\">CNS Depressants, Benzodiazepines, &amp; Alcohol:<\/b> Co-administration markedly increases the risk of profound sedation, life-threatening respiratory depression, coma, and fatal overdose.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"27,3,0\"><b data-path-to-node=\"27,3,0\" data-index-in-node=\"0\">Monoamine Oxidase Inhibitors (MAOIs):<\/b> Caution is required; co-administration may precipitate severe CNS excitation or depression.<\/p>\n<\/li>\n<\/ul>\n<h3 data-path-to-node=\"28\">Clinical Precautions and Monitoring<\/h3>\n<ul data-path-to-node=\"29\">\n<li>\n<p data-path-to-node=\"29,0,0\"><b data-path-to-node=\"29,0,0\" data-index-in-node=\"0\">Strict Opioid Tolerance Definition:<\/b> Patients are considered opioid-tolerant only if they have been taking at least 60 mg oral morphine daily, 30 mg oral oxycodone daily, 8 mg oral hydromorphone daily, or an equianalgesic dose of another opioid for one week or longer.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"29,1,0\"><b data-path-to-node=\"29,1,0\" data-index-in-node=\"0\">Risk of Addiction, Misuse, and Abuse:<\/b> Oxycodone 80 mg carries a substantial risk of opioid use disorder, dependence, and diversion.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"29,2,0\"><b data-path-to-node=\"29,2,0\" data-index-in-node=\"0\">Tolerance &amp; Tapering:<\/b> Extended usage induces physical dependence. Abrupt discontinuation of an 80 mg regimen triggers severe withdrawal symptoms (agitation, lacrimation, diaphoresis, chills, myalgia, severe abdominal cramps). Dosage must be gradually tapered when discontinuing treatment.<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n    <div class=\"xs_social_share_widget xs_share_url after_content \t\tmain_content  wslu-style-1 wslu-share-box-shaped wslu-fill-colored wslu-none wslu-share-horizontal wslu-theme-font-no wslu-main_content\">\n\n\t\t\n        <ul>\n\t\t\t        <\/ul>\n    <\/div>","protected":false},"excerpt":{"rendered":"<p data-path-to-node=\"1\">Oxycodone hydrochloride 80 mg is a high-potency extended-release (ER \/ prolonged-release) opioid formulation indicated exclusively for the management of severe, continuous chronic pain in <b data-path-to-node=\"1\" data-index-in-node=\"188\">opioid-tolerant<\/b> patients requiring high daily opioid dosages.<\/p>\n<h3 data-path-to-node=\"3\">\u00a0<\/h3>","protected":false},"featured_media":6828,"comment_status":"closed","ping_status":"closed","template":"","meta":{"postBodyCss":"","postBodyMargin":[],"postBodyPadding":[],"postBodyBackground":{"backgroundType":"classic","gradient":""}},"product_brand":[],"product_cat":[107],"product_tag":[133],"class_list":["post-6827","product","type-product","status-publish","has-post-thumbnail","product_cat-painkillers","product_tag-oxycodone-hcl-80mg","instock","sale","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.5 (Yoast SEO v28.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Oxycodone HCl 80mg - British Pharmacy<\/title>\n<meta name=\"description\" content=\"Oxycodone HCl 80mg is a potent opioid medication commonly prescribed for managing severe pain. As a semi-synthetic opioid derived from thebaine.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/bristishpharmacy.co.uk\/it\/shop\/oxycodone-hcl-80mg\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Oxycodone HCl 80mg\" \/>\n<meta property=\"og:description\" content=\"Oxycodone hydrochloride 80 mg is a high-potency extended-release (ER \/ prolonged-release) opioid formulation indicated exclusively for the management of severe, continuous chronic pain in opioid-tolerant patients requiring high daily opioid dosages.\u00a0\" \/>\n<meta property=\"og:url\" content=\"https:\/\/bristishpharmacy.co.uk\/it\/shop\/oxycodone-hcl-80mg\/\" \/>\n<meta property=\"og:site_name\" content=\"British Pharmacy\" \/>\n<meta property=\"article:modified_time\" content=\"2026-09-16T10:28:24+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/bristishpharmacy.co.uk\/wp-content\/uploads\/2025\/12\/Oxycodone-HCl-80mg.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"300\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/bristishpharmacy.co.uk\\\/shop\\\/oxycodone-hcl-80mg\\\/\",\"url\":\"https:\\\/\\\/bristishpharmacy.co.uk\\\/shop\\\/oxycodone-hcl-80mg\\\/\",\"name\":\"Oxycodone HCl 80mg - British Pharmacy\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/bristishpharmacy.co.uk\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/bristishpharmacy.co.uk\\\/shop\\\/oxycodone-hcl-80mg\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/bristishpharmacy.co.uk\\\/shop\\\/oxycodone-hcl-80mg\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/bristishpharmacy.co.uk\\\/wp-content\\\/uploads\\\/2025\\\/12\\\/Oxycodone-HCl-80mg.webp\",\"datePublished\":\"2025-12-09T23:02:26+00:00\",\"dateModified\":\"2026-09-16T10:28:24+00:00\",\"description\":\"Oxycodone HCl 80mg is a potent opioid medication commonly prescribed for managing severe pain. 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