{"id":7424,"date":"2026-01-08T10:28:18","date_gmt":"2026-01-08T10:28:18","guid":{"rendered":"https:\/\/bristishpharmacy.co.uk\/?post_type=product&p=7424"},"modified":"2026-09-17T19:44:20","modified_gmt":"2026-09-17T19:44:20","slug":"saxenda-pen","status":"publish","type":"product","link":"https:\/\/bristishpharmacy.co.uk\/nl\/shop\/saxenda-pen\/","title":{"rendered":"Saxenda Pen"},"content":{"rendered":"

\u00a0<\/h1>\n
\n
\n

Clinical Monograph: Saxenda Pen (Liraglutide 6 mg\/mL Delivery System)<\/h3>\n

1. Classification and Chemical Overview<\/h2>\n
    \n
  • \n

    Device & Formulation Context:<\/b> The Saxenda pen is an automated or manual dial-a-dose mechanical delivery system designed for subcutaneous self-administration. Each pen contains 3 mL of solution (totaling 18 mg of liraglutide), and is utilized with disposable, screw-on pen needles (such as NovoFine or NovoTwist).<\/p>\n<\/li>\n

  • \n

    Therapeutic Class:<\/b> Glucagon-Like Peptide-1 (GLP-1) receptor agonist delivery system \/ Antiobesity medication device.<\/p>\n<\/li>\n

  • \n

    Regulatory Status:<\/b> Prescription-only medical device and pharmaceutical combination product, requiring patient instruction on proper priming, needle attachment, and dose verification before use.<\/p>\n<\/li>\n<\/ul>\n

    2. Mechanism of Action and Pharmacodynamics<\/h2>\n
      \n
    • \n

      GLP-1 Receptor Agonism:<\/b> Liraglutide binds to and activates the physiological GLP-1 receptor.<\/p>\n<\/li>\n

    • \n

      Central Appetite Regulation:<\/b> Acts on satiety centers in the hypothalamus to reduce hunger, increase postprandial fullness, and diminish cravings for energy-dense foods.<\/p>\n<\/li>\n

    • \n

      Metabolic & Gastric Modulation:<\/b> Delays gastric emptying and stimulates glucose-dependent insulin secretion while suppressing inappropriate glucagon release.<\/p>\n<\/li>\n<\/ul>\n

      3. Approved Clinical Indications and Dosing Scope<\/h2>\n
        \n
      • \n

        Indications:<\/b> Chronic weight management as an adjunct to a reduced-calorie diet and increased physical activity in adult and pediatric patients (aged 12 years and older) meeting specific body mass index (BMI) thresholds (e.g., initial BMI \u2265<\/span><\/span>30<\/span>\u00a0kg\/m<\/span>2<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span> for obesity, or \u2265<\/span><\/span>27<\/span>\u00a0kg\/m<\/span>2<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span> with weight-related comorbidities).<\/p>\n<\/li>\n

      • \n

        Pen Administration & Titration Regimen:<\/b><\/p>\n

          \n
        • \n

          Initiated at a starting dose of 0.6 mg daily<\/b> delivered via the pen for at least one week.<\/p>\n<\/li>\n

        • \n

          Increased incrementally by 0.6 mg each week (0.6 mg \u2192<\/span><\/span><\/span><\/span><\/span> 1,2 mg \u2192<\/span><\/span><\/span><\/span><\/span> 1,8 mg \u2192<\/span><\/span><\/span><\/span><\/span> 2.4 mg) until reaching the maintenance dose of 3.0 mg daily<\/b>.<\/p>\n<\/li>\n

        • \n

          Priming Protocol:<\/b> Prior to the first injection from a new pen, the user must check the flow by turning the dose selector to the flow check symbol and pressing the push button until a drop appears at the needle tip.<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

          4. Pharmacokinetic Profile<\/h2>\n
            \n
          • \n

            Systemic Absorption:<\/b> Slow absorption following subcutaneous delivery into the abdomen, thigh, or upper arm, with maximum plasma concentration (C<\/span>ma<\/span>x<\/span><\/span><\/span><\/span><\/span>\u200b<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span>) reached 9 to 14 hours post-injection.<\/p>\n<\/li>\n

          • \n

            Distribution & Metabolism:<\/b> Highly bound to plasma proteins (>98%). Degraded endogenously by generalized proteolytic cleavage without requiring specific organ elimination pathways.<\/p>\n<\/li>\n

          • \n

            Elimination:<\/b> Terminal elimination half-life is approximately 13 hours, perfectly matching the 24-hour dosing interval maintained by the pen routine.<\/p>\n<\/li>\n<\/ul>\n

            5. Physiological Effects and Adverse Event Spectrum<\/h2>\n

            Gastrointestinal side effects are the most commonly encountered physiological responses, particularly during dose escalation phases.<\/p>\n

            Adverse Reaction Profile<\/h3>\n
              \n
            • \n

              Very Common (\u2265<\/span><\/span>1\/10<\/span><\/span><\/span><\/span><\/span>):<\/b> Nausea, vomiting, diarrhea, constipation, and decreased appetite.<\/p>\n<\/li>\n

            • \n

              Common (\u2265<\/span><\/span>1\/100<\/span><\/span><\/span><\/span><\/span> to <<\/span><\/span>1\/10<\/span><\/span><\/span><\/span><\/span>):<\/b> Dyspepsia, gastritis, gastroesophageal reflux disease (GERD), abdominal pain, fatigue, asthenia, dizziness, tachycardia, and elevated pancreatic enzymes (lipase\/amylase).<\/p>\n<\/li>\n

            • \n

              Uncommon (\u2265<\/span><\/span>1\/1<\/span>,<\/span>000<\/span><\/span><\/span><\/span><\/span> to <<\/span><\/span>1\/100<\/span><\/span><\/span><\/span><\/span>):<\/b> Cholelithiasis (gallstones), acute cholecystitis, dehydration, acute renal impairment, and localized injection site reactions (bruising or rash).<\/p>\n<\/li>\n

            • \n

              Rare \/ Severe (<1\/1,000):<\/b> Acute pancreatitis, severe hypersensitivity reactions (anaphylaxis and angioedema), and thyroid C-cell tumors.<\/p>\n<\/li>\n<\/ul>\n

              6. Contraindications, Drug Interactions, and Clinical Precautions<\/h2>\n

              Contra-indicaties<\/h3>\n
                \n
              • \n

                Personal or family history of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).<\/p>\n<\/li>\n

              • \n

                Known hypersensitivity to liraglutide or any formulation excipients.<\/p>\n<\/li>\n

              • \n

                Pregnancy and breastfeeding.<\/p>\n<\/li>\n<\/ul>\n

                Key Interacting Factors & Warnings<\/h3>\n
                  \n
                • \n

                  Gastric Emptying Alteration:<\/b> By slowing gastric emptying, liraglutide can impact the absorption rate of concomitantly administered oral medications that require rapid gastrointestinal uptake.<\/p>\n<\/li>\n

                • \n

                  Hypoglycemia Risk:<\/b> Co-administration with insulin secretagogues (such as sulfonylureas) or insulin increases the risk of hypoglycemia; dose adjustments of these agents may be required.<\/p>\n<\/li>\n<\/ul>\n

                  Clinical Precautions and Pen Handling Guidelines<\/h3>\n
                    \n
                  • \n

                    Boxed Warning (Thyroid C-Cell Tumors):<\/b> Causes dose-dependent and duration-dependent thyroid C-cell tumors in rodents; human relevance remains unestablished, but use is strictly contraindicated in patients with MTC or MEN 2.<\/p>\n<\/li>\n

                  • \n

                    Pen Storage & Handling:<\/b> Unused pens must be stored in a refrigerator (2\u2218<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span>C<\/span><\/span><\/span><\/span><\/span><\/span> to 8\u2218<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span>C<\/span><\/span><\/span><\/span><\/span><\/span>). Once in use, the pen can be kept for up to 30 days at room temperature (below 3<\/span>0\u2218<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span>C<\/span><\/span><\/span><\/span><\/span><\/span>) or in a refrigerator. Always remove the needle after each injection and store the pen without a needle attached to prevent leakage and contamination.<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n

                    \n\n\t\t\n
                      \n\t\t\t <\/ul>\n <\/div>","protected":false},"excerpt":{"rendered":"

                      The Saxenda Pen is a pre-filled, multidose subcutaneous injection device containing liraglutide (6 mg\/mL). It is designed to deliver adjustable daily doses (0.6 mg, 1.2 mg, 1.8 mg, 2.4 mg, or 3.0 mg) as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management.<\/p>\n

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