{"id":8111,"date":"2026-04-26T23:27:38","date_gmt":"2026-04-26T23:27:38","guid":{"rendered":"https:\/\/bristishpharmacy.co.uk\/?post_type=product&#038;p=8111"},"modified":"2026-09-16T10:41:15","modified_gmt":"2026-09-16T10:41:15","slug":"contrave-tabletten","status":"publish","type":"product","link":"https:\/\/bristishpharmacy.co.uk\/nl\/shop\/contrave-tabletten\/","title":{"rendered":"Contrave Tablets"},"content":{"rendered":"<h1>\u00a0<\/h1>\n<div class=\"container\">\n<div id=\"model-response-message-contentr_2b204d334dd0203a\" class=\"markdown markdown-main-panel md-content enable-luminous-fast-follows enable-updated-hr-color stronger tutor-markdown-rendering\" dir=\"ltr\" aria-live=\"polite\">\n<h3 data-path-to-node=\"3\">Clinical Monograph: Contrave Extended-Release Tablets<\/h3>\n<div class=\"attachment-container search-images\">\n<div class=\"image-container spark-licensed-center hide-from-message-actions ng-star-inserted\" data-full-size-image-uri=\"https:\/\/lifestylemedicalcenters.com\/wp-content\/uploads\/2023\/04\/Contrave-Pack-Shot.webp\">\n<div class=\"overlay-container hero-overlay-container ng-star-inserted\"><button class=\"image-button ng-star-inserted\"><img fetchpriority=\"high\" decoding=\"async\" class=\"spark-licensed-landscape hero-image loaded\" src=\"https:\/\/encrypted-tbn0.gstatic.com\/images?q=tbn:ANd9GcSEbBiKbVROBc2o4Dkpo5Q26rXyS-05gLYklk2JI05In_iAg9rpYDUDCIjT&amp;s=10\" alt=\"Contrave 8 mg \/ 90 mg extended-release packaging, AI generated\" width=\"470\" height=\"331\" \/><\/button><\/p>\n<div class=\"hero-caption-row ng-star-inserted\">\n<div class=\"caption gds-extended-caption hero-caption ng-star-inserted\" aria-hidden=\"true\">Contrave 8 mg \/ 90 mg extended-release packaging. <span class=\"ng-star-inserted\">Source: Lifestyle Medical Centers<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<h2 data-path-to-node=\"5\">1. Classification and Chemical Overview<\/h2>\n<p data-path-to-node=\"6\">Contrave is an orally administered fixed-dose dual-agent combination tablet containing two active pharmaceutical ingredients:<\/p>\n<ul data-path-to-node=\"7\">\n<li>\n<p data-path-to-node=\"7,0,0\"><b data-path-to-node=\"7,0,0\" data-index-in-node=\"0\">Naltrexone Hydrochloride (8 mg):<\/b> An opioid receptor antagonist chemically designated as 17-(cyclopropylmethyl)-4,5$\\alpha$-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"7,1,0\"><b data-path-to-node=\"7,1,0\" data-index-in-node=\"0\">Bupropion Hydrochloride (90 mg):<\/b> An aminoketone antidepressant chemically designated as <span class=\"math-inline\" data-math=\"(\\pm)\" data-index-in-node=\"88\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mopen\">(<\/span><span class=\"mord\">\u00b1<\/span><span class=\"mclose\">)<\/span><\/span><\/span><\/span><\/span>-1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride.<\/p>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"8\">Under the Anatomical Therapeutic Chemical (ATC) system, this combination is classified under A08AA62 (anti-obesity preparations, centrally acting). It is regulated internationally as a Prescription Only Medicine (POM).<\/p>\n<h2 data-path-to-node=\"9\">2. Mechanism of Action and Pharmacodynamics<\/h2>\n<p data-path-to-node=\"10\">Contrave acts centrally within two key regions of the central nervous system: the arcuate nucleus of the hypothalamus and the mesolimbic dopamine circuit (reward pathway).<\/p>\n<ul data-path-to-node=\"11\">\n<li>\n<p data-path-to-node=\"11,0,0\"><b data-path-to-node=\"11,0,0\" data-index-in-node=\"0\">Hypothalamic Appetite Regulation:<\/b> Bupropion stimulates pro-opiomelanocortin (POMC) neurons in the arcuate nucleus to release <span class=\"math-inline\" data-math=\"\\alpha\" data-index-in-node=\"125\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord mathnormal\">\u03b1<\/span><\/span><\/span><\/span><\/span>-melanocyte-stimulating hormone (<span class=\"math-inline\" data-math=\"\\alpha\" data-index-in-node=\"164\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord mathnormal\">\u03b1<\/span><\/span><\/span><\/span><\/span>-MSH), which activates MC4 receptors to promote satiety and decrease food intake.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"11,1,0\"><b data-path-to-node=\"11,1,0\" data-index-in-node=\"0\">Opioid-Mediated Feedback Inhibition:<\/b> Under baseline conditions, POMC stimulation concurrently releases endogenous opioids (<span class=\"math-inline\" data-math=\"\\beta\" data-index-in-node=\"123\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord mathnormal\">\u03b2<\/span><\/span><\/span><\/span><\/span>-endorphin), which bind to <span class=\"math-inline\" data-math=\"\\mu\" data-index-in-node=\"155\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord mathnormal\">\u03bc<\/span><\/span><\/span><\/span><\/span>-opioid receptors on POMC neurons to exert autoinhibitory negative feedback. Naltrexone blocks these <span class=\"math-inline\" data-math=\"\\mu\" data-index-in-node=\"259\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord mathnormal\">\u03bc<\/span><\/span><\/span><\/span><\/span>-opioid receptors, preventing feedback inhibition and sustaining bupropion-induced firing of POMC neurons.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"11,2,0\"><b data-path-to-node=\"11,2,0\" data-index-in-node=\"0\">Reward Circuit Modulation:<\/b> Synergistic activity across the mesolimbic dopamine pathway reduces food cravings and hedonic reward responses associated with eating.<\/p>\n<\/li>\n<\/ul>\n<h2 data-path-to-node=\"12\">3. Approved Clinical Indications and Dosing Scope<\/h2>\n<p data-path-to-node=\"13\">Licensing for Contrave includes:<\/p>\n<ul data-path-to-node=\"14\">\n<li>\n<p data-path-to-node=\"14,0,0\"><b data-path-to-node=\"14,0,0\" data-index-in-node=\"0\">Chronic Weight Management:<\/b> Adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with:<\/p>\n<ul data-path-to-node=\"14,0,1\">\n<li>\n<p data-path-to-node=\"14,0,1,0,0\">Initial Body Mass Index (BMI) of <span class=\"math-inline\" data-math=\"\\ge 30\\text{ kg\/m}^2\" data-index-in-node=\"33\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">\u2265<\/span><\/span><span class=\"base\"><span class=\"mord\">30<\/span><span class=\"mord\"><span class=\"mord text\">\u00a0kg\/m<\/span><span class=\"msupsub\"><span class=\"vlist-t\"><span class=\"vlist-r\"><span class=\"vlist\"><span class=\"\"><span class=\"sizing reset-size6 size3 mtight\"><span class=\"mord mtight\">2<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span> (obesity), or<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"14,0,1,1,0\">Initial BMI of <span class=\"math-inline\" data-math=\"\\ge 27\\text{ kg\/m}^2\" data-index-in-node=\"15\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">\u2265<\/span><\/span><span class=\"base\"><span class=\"mord\">27<\/span><span class=\"mord\"><span class=\"mord text\">\u00a0kg\/m<\/span><span class=\"msupsub\"><span class=\"vlist-t\"><span class=\"vlist-r\"><span class=\"vlist\"><span class=\"\"><span class=\"sizing reset-size6 size3 mtight\"><span class=\"mord mtight\">2<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span> to <span class=\"math-inline\" data-math=\"&lt; 30\\text{ kg\/m}^2\" data-index-in-node=\"39\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">&lt;<\/span><\/span><span class=\"base\"><span class=\"mord\">30<\/span><span class=\"mord\"><span class=\"mord text\">\u00a0kg\/m<\/span><span class=\"msupsub\"><span class=\"vlist-t\"><span class=\"vlist-r\"><span class=\"vlist\"><span class=\"\"><span class=\"sizing reset-size6 size3 mtight\"><span class=\"mord mtight\">2<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span> (overweight) in the presence of at least one weight-related comorbidity (e.g., controlled hypertension, type 2 diabetes mellitus, or dyslipidemia).<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"15\"><i data-path-to-node=\"15\" data-index-in-node=\"0\">Dosing &amp; Administration Regimen:<\/i><\/p>\n<ul data-path-to-node=\"16\">\n<li>\n<p data-path-to-node=\"16,0,0\"><b data-path-to-node=\"16,0,0\" data-index-in-node=\"0\">Stepwise Escalation Schedule:<\/b> To improve gastrointestinal tolerance, dosage must be titrated weekly over 4 weeks to the target maintenance dose of 2 tablets twice daily (total daily dose: 32 mg naltrexone \/ 360 mg bupropion):<\/p>\n<ul data-path-to-node=\"16,0,1\">\n<li>\n<p data-path-to-node=\"16,0,1,0,0\"><b data-path-to-node=\"16,0,1,0,0\" data-index-in-node=\"0\">Week 1:<\/b> 1 tablet in the morning.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"16,0,1,1,0\"><b data-path-to-node=\"16,0,1,1,0\" data-index-in-node=\"0\">Week 2:<\/b> 1 tablet in the morning, 1 tablet in the evening.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"16,0,1,2,0\"><b data-path-to-node=\"16,0,1,2,0\" data-index-in-node=\"0\">Week 3:<\/b> 2 tablets in the morning, 1 tablet in the evening.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"16,0,1,3,0\"><b data-path-to-node=\"16,0,1,3,0\" data-index-in-node=\"0\">Week 4 onwards (Maintenance):<\/b> 2 tablets in the morning, 2 tablets in the evening.<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li>\n<p data-path-to-node=\"16,1,0\"><b data-path-to-node=\"16,1,0\" data-index-in-node=\"0\">Administration Rules:<\/b> Swallow tablets whole; do <b data-path-to-node=\"16,1,0\" data-index-in-node=\"48\">not<\/b> cut, chew, or crush. Do not take with high-fat meals, as high fat content significantly increases systemic exposure to both drugs.<\/p>\n<\/li>\n<\/ul>\n<h2 data-path-to-node=\"17\">4. Pharmacokinetic Profile and Metabolic Fate<\/h2>\n<ul data-path-to-node=\"18\">\n<li>\n<p data-path-to-node=\"18,0,0\"><b data-path-to-node=\"18,0,0\" data-index-in-node=\"0\">Absorption:<\/b> Both components are absorbed following oral administration. Peak plasma concentration (<span class=\"math-inline\" data-math=\"C_{max}\" data-index-in-node=\"99\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord\"><span class=\"mord mathnormal\">C<\/span><span class=\"msupsub\"><span class=\"vlist-t vlist-t2\"><span class=\"vlist-r\"><span class=\"vlist\"><span class=\"\"><span class=\"sizing reset-size6 size3 mtight\"><span class=\"mord mtight\"><span class=\"mord mathnormal mtight\">ma<\/span><span class=\"mord mathnormal mtight\">x<\/span><\/span><\/span><\/span><\/span><span class=\"vlist-s\">\u200b<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span>) occurs at approximately 2 hours for bupropion and 3 hours for naltrexone.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"18,1,0\"><b data-path-to-node=\"18,1,0\" data-index-in-node=\"0\">Distribution:<\/b> Protein binding is 21% for naltrexone and 84% for bupropion.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"18,2,0\"><b data-path-to-node=\"18,2,0\" data-index-in-node=\"0\">Biotransformation:<\/b><\/p>\n<ul data-path-to-node=\"18,2,1\">\n<li>\n<p data-path-to-node=\"18,2,1,0,0\"><b data-path-to-node=\"18,2,1,0,0\" data-index-in-node=\"0\">Bupropion:<\/b> Extensively metabolized in the liver via CYP2B6 to active metabolites (hydroxybupropion, threohydrobupropion, and erythrohydrobupropion).<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"18,2,1,1,0\"><b data-path-to-node=\"18,2,1,1,0\" data-index-in-node=\"0\">Naltrexone:<\/b> Metabolized in the liver primarily via dihydrodiol dehydrogenase to its major active metabolite, 6$\\beta$-naltrexol.<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li>\n<p data-path-to-node=\"18,3,0\"><b data-path-to-node=\"18,3,0\" data-index-in-node=\"0\">Elimination:<\/b> Excreted predominantly in urine as metabolites. Elimination half-lives (<span class=\"math-inline\" data-math=\"t_{1\/2}\" data-index-in-node=\"85\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord\"><span class=\"mord mathnormal\">t<\/span><span class=\"msupsub\"><span class=\"vlist-t vlist-t2\"><span class=\"vlist-r\"><span class=\"vlist\"><span class=\"\"><span class=\"sizing reset-size6 size3 mtight\"><span class=\"mord mtight\">1\/2<\/span><\/span><\/span><\/span><span class=\"vlist-s\">\u200b<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span>) for bupropion and naltrexone are approximately 21 hours and 5 hours (13 hours for 6$\\beta$-naltrexol), respectively.<\/p>\n<\/li>\n<\/ul>\n<h2 data-path-to-node=\"19\">5. Physiological Effects and Adverse Event Spectrum<\/h2>\n<p data-path-to-node=\"20\">Contrave impacts central neurochemical signaling, blood pressure, heart rate, and gastrointestinal motility.<\/p>\n<h3 data-path-to-node=\"21\">Adverse Drug Reaction Spectrum<\/h3>\n<ul data-path-to-node=\"22\">\n<li>\n<p data-path-to-node=\"22,0,0\"><b data-path-to-node=\"22,0,0\" data-index-in-node=\"0\">Very Common (<span class=\"math-inline\" data-math=\"\\ge 1\/10\" data-index-in-node=\"13\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">\u2265<\/span><\/span><span class=\"base\"><span class=\"mord\">1\/10<\/span><\/span><\/span><\/span><\/span>):<\/b> Nausea, constipation, vomiting, headache, insomnia, dry mouth, dizziness.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"22,1,0\"><b data-path-to-node=\"22,1,0\" data-index-in-node=\"0\">Common (<span class=\"math-inline\" data-math=\"\\ge 1\/100\" data-index-in-node=\"8\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">\u2265<\/span><\/span><span class=\"base\"><span class=\"mord\">1\/100<\/span><\/span><\/span><\/span><\/span> to <span class=\"math-inline\" data-math=\"&lt;1\/10\" data-index-in-node=\"21\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">&lt;<\/span><\/span><span class=\"base\"><span class=\"mord\">1\/10<\/span><\/span><\/span><\/span><\/span>):<\/b> Diarrhea, abdominal pain, anxiety, agitation, hot flashes, hyperhidrosis, dysgeusia, tremor, tinnitus, palpitations, increased blood pressure, heart rate elevation.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"22,2,0\"><b data-path-to-node=\"22,2,0\" data-index-in-node=\"0\">Uncommon (<span class=\"math-inline\" data-math=\"\\ge 1\/1,000\" data-index-in-node=\"10\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">\u2265<\/span><\/span><span class=\"base\"><span class=\"mord\">1\/1<\/span><span class=\"mpunct\">,<\/span><span class=\"mord\">000<\/span><\/span><\/span><\/span><\/span> to <span class=\"math-inline\" data-math=\"&lt;1\/100\" data-index-in-node=\"25\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">&lt;<\/span><\/span><span class=\"base\"><span class=\"mord\">1\/100<\/span><\/span><\/span><\/span><\/span>):<\/b> Confusional state, hallucinations, depression, suicidal ideation, visual impairment, alopecia, acute cholecystitis.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"22,3,0\"><b data-path-to-node=\"22,3,0\" data-index-in-node=\"0\">Rare (&lt;1\/1,000):<\/b> Seizures, serotonin syndrome, severe hepatic dysfunction, anaphylactic reactions.<\/p>\n<\/li>\n<\/ul>\n<h2 data-path-to-node=\"23\">6. Contraindications, Drug Interactions, and Clinical Precautions<\/h2>\n<h3 data-path-to-node=\"24\">Contraindications<\/h3>\n<ul data-path-to-node=\"25\">\n<li>\n<p data-path-to-node=\"25,0,0\">Uncontrolled hypertension.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"25,1,0\">Seizure disorders or history of seizures.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"25,2,0\">Current or prior diagnosis of bulimia or anorexia nervosa (due to heightened seizure risk).<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"25,3,0\">Chronic opioid therapy, acute opioid withdrawal, or failed opioid challenge.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"25,4,0\">Concomitant use of monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping MAOIs.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"25,5,0\">Abrupt withdrawal of alcohol, benzodiazepines, barbiturates, or antiepileptic drugs.<\/p>\n<\/li>\n<\/ul>\n<h3 data-path-to-node=\"26\">Key Drug Interactions<\/h3>\n<ul data-path-to-node=\"27\">\n<li>\n<p data-path-to-node=\"27,0,0\"><b data-path-to-node=\"27,0,0\" data-index-in-node=\"0\">Opioids:<\/b> Naltrexone blocks the therapeutic effects of opioid analgesics; administration to opioid-dependent individuals precipitates acute opioid withdrawal.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"27,1,0\"><b data-path-to-node=\"27,1,0\" data-index-in-node=\"0\">CYP2B6 Inhibitors\/Inducers:<\/b> Strong CYP2B6 inhibitors (e.g., ticlopidine, clopidogrel) increase bupropion exposure; do not exceed 1 tablet twice daily. CYP2B6 inducers (e.g., ritonavir, carbamazepine) decrease bupropion exposure and efficacy.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"27,2,0\"><b data-path-to-node=\"27,2,0\" data-index-in-node=\"0\">Drugs Metabolized by CYP2D6:<\/b> Bupropion inhibits CYP2D6, increasing plasma levels of co-administered drugs cleared via this pathway (e.g., certain antidepressants, antipsychotics, <span class=\"math-inline\" data-math=\"\\beta\" data-index-in-node=\"179\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord mathnormal\">\u03b2<\/span><\/span><\/span><\/span><\/span>-blockers, and Type 1C antiarrhythmics).<\/p>\n<\/li>\n<\/ul>\n<h3 data-path-to-node=\"28\">Clinical Precautions and Monitoring<\/h3>\n<ul data-path-to-node=\"29\">\n<li>\n<p data-path-to-node=\"29,0,0\"><b data-path-to-node=\"29,0,0\" data-index-in-node=\"0\">Boxed Warning (Suicidality &amp; Neuropsychiatric Reactions):<\/b> Bupropion is an antidepressant component; monitor patients for emergence of suicidal thoughts, depression, mania, or unusual changes in mood or behavior, particularly in adolescents and young adults.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"29,1,0\"><b data-path-to-node=\"29,1,0\" data-index-in-node=\"0\">Seizure Risk:<\/b> Bupropion can cause dose-related seizures. Do not exceed maximum recommended total daily dose of 4 tablets (32 mg\/360 mg).<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"29,2,0\"><b data-path-to-node=\"29,2,0\" data-index-in-node=\"0\">Blood Pressure &amp; Pulse:<\/b> Can increase systolic and diastolic blood pressure and resting heart rate. Monitor blood pressure and pulse prior to initiating treatment and regularly throughout therapy.<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n    <div class=\"xs_social_share_widget xs_share_url after_content \t\tmain_content  wslu-style-1 wslu-share-box-shaped wslu-fill-colored wslu-none wslu-share-horizontal wslu-theme-font-no wslu-main_content\">\n\n\t\t\n        <ul>\n\t\t\t        <\/ul>\n    <\/div> \n","protected":false},"excerpt":{"rendered":"<p data-path-to-node=\"1\">Contrave (naltrexone hydrochloride 8 mg \/ bupropion hydrochloride 90 mg) is a fixed-dose combination extended-release tablet indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with obesity or overweight.<\/p>\n<h3 data-path-to-node=\"3\">\u00a0<\/h3>","protected":false},"featured_media":8112,"comment_status":"closed","ping_status":"closed","template":"","meta":{"postBodyCss":"","postBodyMargin":[],"postBodyPadding":[],"postBodyBackground":{"backgroundType":"classic","gradient":""}},"product_brand":[],"product_cat":[105],"product_tag":[246],"class_list":["post-8111","product","type-product","status-publish","has-post-thumbnail","product_cat-weight-loss","product_tag-contrave-tablets","instock","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.5 (Yoast SEO v28.5) - 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