{"id":8114,"date":"2026-04-26T23:37:09","date_gmt":"2026-04-26T23:37:09","guid":{"rendered":"https:\/\/bristishpharmacy.co.uk\/?post_type=product&#038;p=8114"},"modified":"2026-09-16T10:40:04","modified_gmt":"2026-09-16T10:40:04","slug":"demerol-100mg","status":"publish","type":"product","link":"https:\/\/bristishpharmacy.co.uk\/nl\/shop\/demerol-100mg\/","title":{"rendered":"Demerol 100 mg"},"content":{"rendered":"<h1>\u00a0<\/h1>\n<div class=\"container\">\n<div id=\"model-response-message-contentr_b1667908c1ff194d\" class=\"markdown markdown-main-panel md-content enable-luminous-fast-follows enable-updated-hr-color stronger tutor-markdown-rendering\" dir=\"ltr\" aria-live=\"polite\">\n<h3 data-path-to-node=\"3\">Clinical Monograph: Demerol 100 mg (Meperidine HCl)<\/h3>\n<div class=\"attachment-container search-images\">\n<div class=\"image-container spark-licensed-center hide-from-message-actions ng-star-inserted\" data-full-size-image-uri=\"https:\/\/www.pfizerhospitalus.com\/sites\/default\/files\/child\/images\/Drug-0409-1181-30-Demerol-Meperdine-Hydrochloride-Injection-USP.jpg\">\n<div class=\"overlay-container hero-overlay-container ng-star-inserted\"><button class=\"image-button ng-star-inserted\"><img fetchpriority=\"high\" decoding=\"async\" class=\"spark-licensed-square hero-image loaded\" src=\"https:\/\/encrypted-tbn0.gstatic.com\/images?q=tbn:ANd9GcQ9O8QtLJBVShWmTlh140lcKWI_bWgNfb62rDCnB3g_Okv5I7BceCoYHETp&amp;s=10\" alt=\"Demerol (meperidine HCl) injection product vial, AI generated\" width=\"316\" height=\"316\" \/><\/button><\/p>\n<div class=\"hero-caption-row ng-star-inserted\">\n<div class=\"caption gds-extended-caption hero-caption ng-star-inserted\" aria-hidden=\"true\">Demerol (meperidine HCl) injection product vial. <span class=\"ng-star-inserted\">Source: Pfizer Hospital US<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<h2 data-path-to-node=\"5\">1. Classification and Chemical Overview<\/h2>\n<p data-path-to-node=\"6\">Meperidine (also referred to internationally as pethidine) is a synthetic opioid belonging to the phenylpiperidine chemical class. Chemically designated as ethyl 1-methyl-4-phenylpiperidine-4-carboxylate hydrochloride, it was historically the first synthetic opioid synthesized for clinical use. Under the Anatomical Therapeutic Chemical (ATC) classification system, meperidine is indexed under N02AB02.<\/p>\n<p data-path-to-node=\"7\">Demerol is classified globally as a tightly controlled substance (e.g., Schedule II under the US Controlled Substances Act; Class A \/ Schedule 2 Controlled Drug in the UK) with high potential for physical dependence, addiction, and misuse. It is available strictly as a Prescription Only Medicine (POM).<\/p>\n<h2 data-path-to-node=\"8\">2. Mechanism of Action and Pharmacodynamics<\/h2>\n<p data-path-to-node=\"9\">Meperidine exerts its principal therapeutic actions by acting as an agonist at central and peripheral opioid receptors, while also displaying weak local anesthetic and anticholinergic activity:<\/p>\n<ul data-path-to-node=\"10\">\n<li>\n<p data-path-to-node=\"10,0,0\"><b data-path-to-node=\"10,0,0\" data-index-in-node=\"0\"><span class=\"math-inline\" data-math=\"\\mu\" data-index-in-node=\"0\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord mathnormal\">\u03bc<\/span><\/span><\/span><\/span><\/span>-Opioid Receptor Activation:<\/b> Binds primarily as a full agonist at <span class=\"math-inline\" data-math=\"\\mu\" data-index-in-node=\"69\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord mathnormal\">\u03bc<\/span><\/span><\/span><\/span><\/span>-opioid receptors, inhibiting presynaptic neurotransmitter release (substance P, glutamate) in the spinal cord dorsal horn and hyperpolarizing postsynaptic neurons.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"10,1,0\"><b data-path-to-node=\"10,1,0\" data-index-in-node=\"0\">Serotonin Reuptake Inhibition:<\/b> Uniquely among classic opioids, meperidine acts as a weak serotonin reuptake inhibitor (SRI). This contributes to a high risk of fatal <b data-path-to-node=\"10,1,0\" data-index-in-node=\"166\">serotonin syndrome<\/b> when combined with serotonergic agents.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"10,2,0\"><b data-path-to-node=\"10,2,0\" data-index-in-node=\"0\">Anticholinergic &amp; Local Anesthetic Effects:<\/b> Exhibits mild atropine-like anticholinergic properties (causing dry mouth, tachycardia, and mydriasis rather than classical opioid miosis) and blocks voltage-gated sodium channels at high concentrations.<\/p>\n<\/li>\n<\/ul>\n<h2 data-path-to-node=\"11\">3. Approved Clinical Indications and Dosing Scope<\/h2>\n<p data-path-to-node=\"12\">Licensing for Demerol 100 mg includes:<\/p>\n<ul data-path-to-node=\"13\">\n<li>\n<p data-path-to-node=\"13,0,0\"><b data-path-to-node=\"13,0,0\" data-index-in-node=\"0\">Short-Term Acute Pain Management:<\/b> Short-term relief of moderate to severe acute pain (e.g., post-operative pain, acute obstetric analgesia).<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"13,1,0\"><b data-path-to-node=\"13,1,0\" data-index-in-node=\"0\">Preoperative Sedation:<\/b> Adjunct to anesthesia for preoperative medication and shivering management.<\/p>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"14\"><i data-path-to-node=\"14\" data-index-in-node=\"0\">Dosing &amp; Administration Regimen:<\/i><\/p>\n<ul data-path-to-node=\"15\">\n<li>\n<p data-path-to-node=\"15,0,0\"><b data-path-to-node=\"15,0,0\" data-index-in-node=\"0\">Short-Duration Restriction:<\/b> Guidelines strongly restrict usage to short-term treatment (<span class=\"math-inline\" data-math=\"\\le 48\\text{ hours}\" data-index-in-node=\"88\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">\u2264<\/span><\/span><span class=\"base\"><span class=\"mord\">48<\/span><span class=\"mord text\"><span class=\"mord\">\u00a0hours<\/span><\/span><\/span><\/span><\/span><\/span>) with total daily doses not exceeding 600 mg\/day to limit normeperidine accumulation.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"15,1,0\"><b data-path-to-node=\"15,1,0\" data-index-in-node=\"0\">Oral vs. Parenteral:<\/b> Available in 100 mg oral tablet form or as parenteral solution (100 mg\/mL). Oral administration is inefficient due to high first-pass hepatic metabolism.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"15,2,0\"><b data-path-to-node=\"15,2,0\" data-index-in-node=\"0\">Administration Integrity:<\/b> Parenteral administration must be given via slow intravenous injection or deep intramuscular injection to minimize local tissue damage and histamine release.<\/p>\n<\/li>\n<\/ul>\n<h2 data-path-to-node=\"16\">4. Pharmacokinetic Profile and Metabolic Fate<\/h2>\n<ul data-path-to-node=\"17\">\n<li>\n<p data-path-to-node=\"17,0,0\"><b data-path-to-node=\"17,0,0\" data-index-in-node=\"0\">Absorption:<\/b> Rapidly absorbed after oral administration, but absolute bioavailability is low (~50% to 60%) due to extensive hepatic first-pass metabolism. Onset of action occurs within 10 to 15 minutes post-injection or 30 to 45 minutes post-oral dose.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"17,1,0\"><b data-path-to-node=\"17,1,0\" data-index-in-node=\"0\">Distribution:<\/b> Protein binding is moderate (~65% to 75%, primarily to <span class=\"math-inline\" data-math=\"\\alpha_1\" data-index-in-node=\"69\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord\"><span class=\"mord mathnormal\">\u03b1<\/span><span class=\"msupsub\"><span class=\"vlist-t vlist-t2\"><span class=\"vlist-r\"><span class=\"vlist\"><span class=\"\"><span class=\"sizing reset-size6 size3 mtight\"><span class=\"mord mtight\">1<\/span><\/span><\/span><\/span><span class=\"vlist-s\">\u200b<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span>-acid glycoprotein). Readily crosses the blood-brain and placental barriers.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"17,2,0\"><b data-path-to-node=\"17,2,0\" data-index-in-node=\"0\">Biotransformation:<\/b> Extensively metabolised in the liver via two distinct pathways:<\/p>\n<ul data-path-to-node=\"17,2,1\">\n<li>\n<p data-path-to-node=\"17,2,1,0,0\"><b data-path-to-node=\"17,2,1,0,0\" data-index-in-node=\"0\"><span class=\"math-inline\" data-math=\"N\" data-index-in-node=\"0\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord mathnormal\">N<\/span><\/span><\/span><\/span><\/span>-Demethylation (Major Active Pathway):<\/b> Mediated by CYP2B6, CYP3A4, and CYP2C19 to form <b data-path-to-node=\"17,2,1,0,0\" data-index-in-node=\"88\">normeperidine<\/b>, a neurotoxic active metabolite with half the analgesic potency but twice the CNS-excitatory potency of parent meperidine.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"17,2,1,1,0\"><b data-path-to-node=\"17,2,1,1,0\" data-index-in-node=\"0\">Hydrolysis:<\/b> Hydrolyzed by hepatic carboxylesterases to inactive meperidinic acid, followed by glucuronide conjugation.<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li>\n<p data-path-to-node=\"17,3,0\"><b data-path-to-node=\"17,3,0\" data-index-in-node=\"0\">Elimination:<\/b> Excreted primarily via the kidneys in urine. Parent meperidine has an elimination half-life (<span class=\"math-inline\" data-math=\"t_{1\/2}\" data-index-in-node=\"106\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord\"><span class=\"mord mathnormal\">t<\/span><span class=\"msupsub\"><span class=\"vlist-t vlist-t2\"><span class=\"vlist-r\"><span class=\"vlist\"><span class=\"\"><span class=\"sizing reset-size6 size3 mtight\"><span class=\"mord mtight\">1\/2<\/span><\/span><\/span><\/span><span class=\"vlist-s\">\u200b<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span>) of 3 to 5 hours. However, the neurotoxic metabolite <b data-path-to-node=\"17,3,0\" data-index-in-node=\"167\">normeperidine<\/b> has an extended half-life of 15 to 30 hours (exceeding 35 hours in renal impairment).<\/p>\n<\/li>\n<\/ul>\n<h2 data-path-to-node=\"18\">5. Physiological Effects and Adverse Event Spectrum<\/h2>\n<p data-path-to-node=\"19\">Meperidine depresses central respiratory drive, reduces smooth muscle tone in select visceral tissue, and induces CNS excitation via normeperidine accumulation.<\/p>\n<h3 data-path-to-node=\"20\">Adverse Drug Reaction Spectrum<\/h3>\n<ul data-path-to-node=\"21\">\n<li>\n<p data-path-to-node=\"21,0,0\"><b data-path-to-node=\"21,0,0\" data-index-in-node=\"0\">Very Common (<span class=\"math-inline\" data-math=\"\\ge 1\/10\" data-index-in-node=\"13\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">\u2265<\/span><\/span><span class=\"base\"><span class=\"mord\">1\/10<\/span><\/span><\/span><\/span><\/span>):<\/b> Sedation, dizziness, lightheadedness, nausea, vomiting, diaphoresis.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"21,1,0\"><b data-path-to-node=\"21,1,0\" data-index-in-node=\"0\">Common (<span class=\"math-inline\" data-math=\"\\ge 1\/100\" data-index-in-node=\"8\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">\u2265<\/span><\/span><span class=\"base\"><span class=\"mord\">1\/100<\/span><\/span><\/span><\/span><\/span> to <span class=\"math-inline\" data-math=\"&lt;1\/10\" data-index-in-node=\"21\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">&lt;<\/span><\/span><span class=\"base\"><span class=\"mord\">1\/10<\/span><\/span><\/span><\/span><\/span>):<\/b> Tachycardia, dry mouth, urinary retention, constipation, headache, euphoria, dysphoria, pruritus, histamine release.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"21,2,0\"><b data-path-to-node=\"21,2,0\" data-index-in-node=\"0\">Uncommon (<span class=\"math-inline\" data-math=\"\\ge 1\/1,000\" data-index-in-node=\"10\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">\u2265<\/span><\/span><span class=\"base\"><span class=\"mord\">1\/1<\/span><span class=\"mpunct\">,<\/span><span class=\"mord\">000<\/span><\/span><\/span><\/span><\/span> to <span class=\"math-inline\" data-math=\"&lt;1\/100\" data-index-in-node=\"25\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mrel\">&lt;<\/span><\/span><span class=\"base\"><span class=\"mord\">1\/100<\/span><\/span><\/span><\/span><\/span>):<\/b> Hypotension, syncope, disorientation, muscle twitching, tremors, hyperreflexia.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"21,3,0\"><b data-path-to-node=\"21,3,0\" data-index-in-node=\"0\">Rare \/ Severe (&lt;1\/1,000):<\/b> Respiratory depression, grand mal seizures (secondary to normeperidine toxicity), serotonin syndrome, severe bradycardia, anaphylaxis.<\/p>\n<\/li>\n<\/ul>\n<h2 data-path-to-node=\"22\">6. Contraindications, Drug Interactions, and Clinical Precautions<\/h2>\n<h3 data-path-to-node=\"23\">Contra-indicaties<\/h3>\n<ul data-path-to-node=\"24\">\n<li>\n<p data-path-to-node=\"24,0,0\"><b data-path-to-node=\"24,0,0\" data-index-in-node=\"0\">MAOI Co-administration:<\/b> Concomitant use with or within 14 days of Monoamine Oxidase Inhibitors (MAOIs) is strictly contraindicated due to unpredictable, often fatal reactions (hypertensive crisis or severe serotonin syndrome).<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"24,1,0\">Significant respiratory depression or acute severe bronchial asthma.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"24,2,0\">Severe renal impairment or end-stage renal disease (ESRD) due to normeperidine accumulation.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"24,3,0\">Hypersensitivity to meperidine or formulation excipients.<\/p>\n<\/li>\n<\/ul>\n<h3 data-path-to-node=\"25\">Key Drug Interactions<\/h3>\n<ul data-path-to-node=\"26\">\n<li>\n<p data-path-to-node=\"26,0,0\"><b data-path-to-node=\"26,0,0\" data-index-in-node=\"0\">Monoamine Oxidase Inhibitors (MAOIs) &amp; SSRIs\/SNRIs:<\/b> Co-administration triggers severe, life-threatening serotonin syndrome (hyperthermia, rigidity, autonomic instability, coma) or severe respiratory depression.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"26,1,0\"><b data-path-to-node=\"26,1,0\" data-index-in-node=\"0\">CNS Depressants, Benzodiazepines, &amp; Alcohol:<\/b> Produces additive central nervous system depression, markedly increasing the risk of profound sedation, respiratory arrest, coma, and death.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"26,2,0\"><b data-path-to-node=\"26,2,0\" data-index-in-node=\"0\">CYP Inducers (e.g., Phenobarbital, Phenytoin, Rifampicin):<\/b> Accelerate <span class=\"math-inline\" data-math=\"N\" data-index-in-node=\"70\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord mathnormal\">N<\/span><\/span><\/span><\/span><\/span>-demethylation to normeperidine, increasing CNS toxicity and seizure risks while diminishing analgesia.<\/p>\n<\/li>\n<\/ul>\n<h3 data-path-to-node=\"27\">Clinical Precautions and Monitoring<\/h3>\n<ul data-path-to-node=\"28\">\n<li>\n<p data-path-to-node=\"28,0,0\"><b data-path-to-node=\"28,0,0\" data-index-in-node=\"0\">Boxed Warning (Normeperidine Toxicity &amp; Seizures):<\/b> Accumulation of normeperidine causes progressive CNS excitation, manifesting as irritability, myoclonus, tremors, and generalized grand mal seizures. Avoid use in patients with renal dysfunction, elderly patients, or for continuous long-term pain control.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"28,1,0\"><b data-path-to-node=\"28,1,0\" data-index-in-node=\"0\">Opioid Addiction and Misuse:<\/b> Carries significant risks of misuse, addiction, and overdose.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"28,2,0\"><b data-path-to-node=\"28,2,0\" data-index-in-node=\"0\">Renal Failure Hazard:<\/b> Decreased renal clearance prolongs normeperidine elimination, making meperidine inappropriate for chronic or subacute pain management in patients with altered kidney function.<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n    <div class=\"xs_social_share_widget xs_share_url after_content \t\tmain_content  wslu-style-1 wslu-share-box-shaped wslu-fill-colored wslu-none wslu-share-horizontal wslu-theme-font-no wslu-main_content\">\n\n\t\t\n        <ul>\n\t\t\t        <\/ul>\n    <\/div>","protected":false},"excerpt":{"rendered":"<p data-path-to-node=\"1\">Demerol 100 mg (meperidine hydrochloride or pethidine) is a fast-acting synthetic phenylpiperidine opioid agonist indicated for the short-term management of acute severe pain. Due to the accumulation of its neurotoxic metabolite (normeperidine), its modern clinical utility is strictly restricted to acute, short-duration settings.<\/p>\n<h3 data-path-to-node=\"3\">\u00a0<\/h3>","protected":false},"featured_media":8119,"comment_status":"closed","ping_status":"closed","template":"","meta":{"postBodyCss":"","postBodyMargin":[],"postBodyPadding":[],"postBodyBackground":{"backgroundType":"classic","gradient":""}},"product_brand":[],"product_cat":[15],"product_tag":[247],"class_list":["post-8114","product","type-product","status-publish","has-post-thumbnail","product_cat-uncategorized","product_tag-demerol-100mg","instock","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.5 (Yoast SEO v28.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Demerol 100mg - British Pharmacy<\/title>\n<meta name=\"description\" content=\"\u00a0Demerol 100mg is a brand name for meperidine hydrochloride, a synthetic opioid analgesic (painkiller) from the phenylpiperidine class.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/bristishpharmacy.co.uk\/nl\/shop\/demerol-100mg\/\" \/>\n<meta property=\"og:locale\" content=\"nl_NL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Demerol 100mg\" \/>\n<meta property=\"og:description\" content=\"Demerol 100 mg (meperidine hydrochloride or pethidine) is a fast-acting synthetic phenylpiperidine opioid agonist indicated for the short-term management of acute severe pain. 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